Flashcards in inflammation Deck (62):
what are the clinical signs and symptoms of inflammation?
how does vascularity change during acute inflammation?
- increased vascular permeability
what do the changes in vascularity (during ACUTE inflammation) cause?
fluid (edema) and inflammatory cell accumulation
in the tissue
vasodilation results in the relaxation of ________ arterioles
what is vasodilation mediated by during acute inflammation/
what is transudate?
Low protein content, low specific gravity fluid
when is non-inflammatory transudate present? what about inflammatory transudate?
Non-inflammatory - intact endothelium
Inflammatory – early endothelial contraction
what is exudate?
High protein content, high specific gravity fluid
what are the types of exudate? (theres 3 types)
Fibrinous – high protein, few cells
Purulent – high protein, many cells
Sanguineous – high protein, blood
T/F: the occurrence of transudate fluid is a result of fluid and protein leakage
FALSE- thats exudate
transudate is just fluid leakage
___________ contractions lead to an immediate increase in permeability
____________ is a delayed response (develops 4-6 hours after injury) and causes further vascular permeability
what mediates endothelial contraction?
PAF, histamine, bradykinin, leukotrienes
what mediates endothelial cell retraction following DIRECT endothelial injury?
IL-1, TNF, IFN-gamma
_________ is mediated by the injurious agent, or by ROS/enzymes from NEUTROPHILS
direct endothelial injury
what substances are secreted by injured cells to increase the pain perception during inflammation?
the fever ("heat") associated with inflammation is associated with what cellular molecules?
what changes are seen in activated endothelial cells during inflammation? (4 changes)
1) Produce PGI2 and NO (vasodilation)
2) Contraction / retraction
3) Increase expression of adhesion molecules
4) Increase synthesis of mediators
what molecules facilitate leukocyte Adhesion?