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Flashcards in Neoplasia 1 Deck (30):
1

what is the definition of a "neoplasia"?

“new growth” - loss of responsiveness to normal growth controls

2

Neoplasms behave as _______, competing with normal cells

parasites

3

_________ is the study of neoplasms

oncology

4

the term "malignant" is also known as what?

cancer

5

Most benign tumors are designated by attaching the suffix “______” to their cell type of origin

-oma


e.g., fibroma, osteoma

6

what is a "Adenoma"?

benign gland-forming epithelial tumor or tumor derived from glandular tissue

7

what is a papilloma?

- benign surface epithelial tumor

- characterized by numerous finger-like (papillary) projections

8

a __________ is a proliferation of tissue normally found at that site

Hamartoma

9

___________ are collections of tissue not normally found in that anatomic site - “heterotopic rest”

Choristoma

10

what is a "teratoma"?

neoplasm derived from more than one germ layer

11

Mesenchymal malignancies are termed “_________”

sarcomas

-e.g., fibrosarcoma or osteosarcoma

12

Epithelial malignancies are termed “_________”

carcinoma

- e.g., squamous cell carcinoma or adenocarcinoma

13

what does "differentiation" refer to in respect to neoplasms?

refers to how well the parenchymal cells of the neoplasm resemble their normal tissue of origin

14

________ tumors almost always closely resemble normal tissue microscopically

benign

15

Malignant tumors may have a wide range of ___________

differentiation

16

what is the difference between high-grade, and low-grade, malignancies?

low-grade: resemble normal tissue to a large extent

high-grade: poorly-differentiated malignancies are termed “anaplastic”

17

what is the definition of "Anaplasia"?

- Malignancies composed of poorly differentiated cells

- most extreme disturbance in cell growth and differentiation

18

name the features of Anaplasias

Malignancies composed of poorly differentiated cells:

-pleomorphism

-nuclear hyperchromatism and variation in nuclear size and shape

-numerous and atypical mitoses

19

___________ are disorderly, but non-neoplastic growth or proliferation

dysplasias

20

T/F: dysplasias have the potential to become invasive carcinomas

True

21

____________ malignancies can also grow relatively slowly, while _________________ lesions tend to grow rapidly

Well-differentiated

poorly-differentiated

22

Some tumors outgrow their blood supply, resulting in areas of what?

ischemic necrosis

23

how do malignancies grow?

grow by:
- infiltration

-invasion

- destruction of surrounding tissue

24

Malignancies lack well-defined ______

capsules

25

what is the MOST RELIABLE FEATURE for distinguishing malignant from benign tumors�

Local invasiveness

26

what is a Seminoma?

testicular malignancy

27

____________ is the name given to pleural malignancies

mesothelioma

28

The most severe form of epithelial dysplasia is referred to as ______________

carcinoma-in-situ

29

what are the characteristics of Carcinoma-in-situ?

- has all of the microscopic features of cancer

BUT

- the atypical cells have not invaded into the host.

30

Hemangiomas and neurofibromas are unique benign neoplasms because they lack __________

a capsule