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Flashcards in Integration of metabolism Deck (35)
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1

metabolism

sum of total of all the chemical reactions that on in living cells

2

homeostasis

metabolic condition that is the result of dynamic processes to maintain a constant internal environment despite a changing external environment

3

blood pH

7.4
=> due to homeostasis

4

negative feedback

acts to resist any deviation

5

Anabolism

building complex compounds, requires energy
ex: aa + aa -> protein

6

Catabolism

breakdown large molecules into smaller ones, releases energy
ex: TG -> Glycerol + FA

7

Fed state

anabolism
lots of nutrients -> requires energy

8

Body uses mostly __ for its energy needs

carbs & fats

9

PYRUVATE

- CAN make glucose
- 3 C compound

10

ACETYLCOA

- CAN'T male glucose
- 2 carbon compound with CoA

11

During digestion :
Protein ->
Carbohydrates ->
Fat ->

amino acids
glucose
glycerol + fatty acids

12

amino acids ->
- ketogenic ->
- glucogenic ->
glucose
glycerol ->
fatty acids ->

amino acids -> TCA cycle
- ketogenic -> acetylcoa
- glucogenic -> pyruvate
glucose pyruvate
glycerol -> pyruvate
fatty acids -> acetylcoa

13

What can't make glucose?

- fatty acids
- ketogenic amino acids
=> acetyl coa

14

What can make glucose?

- glucogenic amino acids
- glycerol
=> pyruvate

15

Glucogenic amino acids can go to :

- pyruvate -> TCA
OR
- TCA cycle directly

16

Body can't make __ aa

essential

17

Functions of acetylcoa

What can make acetylcoa?

- synthesize fats
- generate ATP

- any molecule can make acetylcoa: amino acids, fatty acids, glycerol, glucose and therefore make FAT

18

Which molecule can make FAT?

amino acids, fatty acids, glycerol, glucose

19

Lipogenesis

Liver takes excess glucose and synthesises fat
=
acetyl coa is converted to triglyceride to make fat

20

Pyruvate can be converted to

- acetyl coa
- lactate
- glucose

21

FED state

Carbs - glucose -
fats - fa -
proteins - aa -

Carbs - glucose - liver & muscle glycogen stores + body fat stores

fats - fa - body fat stores

proteins - aa - body fat stores + body proteins + loss of nitrogen in urine (urea)

22

SHORT term fast
liver & glycogen stores ->

body fat stores ->

liver & glycogen stores -> glucose -> energy for brain, nervous system, RBC + energy for other cells

body fat stores -> fatty acids -> energy for other cells

23

LONG term fast
body protein ->
body fat ->

body protein ->
AA-> loss of nitrogen in urine +
AA-> glucose -> energy for brain, RBC, NS, other cells
AA-> ketone bodies -> energy for brain, RBC, NS, other cells

body fat ->
FA-> ketone bodies -> energy for brain, RBC, NS, other cells
FA-> energy for other cells

24

glucose concentration in spinal fluid = of plasma glucose

2/3

25

Eating too much fat promotes fat oxidation

FALSE

26

Which energy yielding nutrients are broken down to acetylcoa?

protein
carb
fat

27

Acetylcoa can :

enter tca cycle or make fat

28

Fatty acids can/can't be used to make glucose

can't

29

Excess glucose converted to fat happens in which state?

fed state

30

Before going to liver, glucose goes through

Hepatic portal vein