INTEGRATION OF METABOLISM Flashcards Preview

#‼️BIOCHEMISTRY - PLE TOPNOTCH 2020 > INTEGRATION OF METABOLISM > Flashcards

Flashcards in INTEGRATION OF METABOLISM Deck (33)
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1

Stimulus for secretion of INSULIN

• Ingestion of glucose and amino acids

• Cholecystokinin and gastricinhibitory polypeptide

2

What is the transporter of Fructose in the enterocytes?

GLUT 5

3

SGLT - 1 transport what substances?

Na, Glucose and Galactose

4

Where are bile salts absorbed?

ileum (enterohepatic circulation)

5

Enzymes in the fasting state should be __________ for them to be active. 

PHOSPHORYLATED. 

6

In the oral cavity, what digests glycogen and starch, yielding short branched and unbranched oligosaccharides called dextrins? 

Salivary α-amylase

7

Majority of absorption of monosaccharides occurs in the ____

duodenum and upper jejunum

8

Ketogenesis and ketolysis happens both in the fasting state. TRUE or FALSE. 

TRUE

9

In the jejunum, free fatty acids, cholesterol, 2-monoacylglycerols, and fat-soluble vitamins form disk-shaped ________, which come in contact with the epithelium by the enterocytes, allowing absorption.

mixed micelles

10

What transporters are present in the APICAL MEMBRANE / LUMINAL SIDE of the enterocytes?

SGLT-1 and GLUT 5

11

Fructose is absorbed in the enterocytes via what transport mechanism?

facilitated diffusion

* This does not require ATP, and the transport protein is GLUT 5.

12

RBC's source of fuel during fed and fasting state. 

Use glucose exclusively as fuel coz they don't have mitochondria

13

In the endoplasmic reticulum of enterocytes, the dietary lipids are converted back to TAGs and cholesteryl esters and are packaged as _______ and released into the lymphatic circulation (lacteals).

chylomicrons

14

Pathways increased in the well fed state

• Glucose uptake

• Glycogenesis

• Protein synthesis

• Lipogenesis

15

Stimulus for secretion of GLucagon 

Actual or potential hypoglycemia

16

_______ located on the brush border releases free amino acids from dipeptides and oligopeptides

Aminopeptidases

17

True or false. Short- and medium-chain fatty acids are absorbed without the need for micelles.

TRUE

18

in the SI, what digests TAGs (into 2-monoacylglycerols and 2 free fatty acids)?

Pancreatic lipase

19

Free amino acids are taken to the portal circulation via what transport mechanism out of the enterocytes?

facilitated diffusion

20

Gluconeogenesis happens in what organs?

Liver and Kidney

21

2ND MESSENGER OF GLUCAGON 

cAMP

22

GLUT 2 transports what substances?

Glucose, Galactose and Fructose 

23

In the SI, what digests choleteryl esters (into cholesterol and fatty acid)?

cholesteryl ester hydrolase

24

Enzymes in the well fed state should be __________ for them to be active. 

DEPHOSPHORYLATED 

25

Pathways increased in the fasting state 

• Gluconeogenesis

• Glycogenolysis

• Uptake of amino acids

• Beta-oxidation

• Ketogenesis

26

glucose and galactose are transported into the enterocytes (intestinal mucosal cells) via what transport mechanism?

secondary active transport

*This requires ATP. Glucose and galactose are transported with the Na+ ion, through the transport protein SGLT.

27

2nd messenger of insulin 

Tyrosine kinase

28

________ activates trypsinogen, and trypsin is capable of activating all the rest, including itself

Enteropeptidase

29

What transporters are present in the BASOLATERAL MEMBRANE of the enterocytes?

GLUT-2

30

What are the sources of fuel of the brain during fasting?

glucose and ketone bodies