Integument Barrier Infection - Dennis Flashcards Preview

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Flashcards in Integument Barrier Infection - Dennis Deck (38):
1

What is another term for the hypodermis? 3

Subcutaneous

2

What are the four roles of the integument? 3

Protection - Physcial, chemical, biological

Sensation & excretion

Thermoregulatin

Synthesis of Vitamin D3

3

What two things does thick skin lack? 5

Lacks:
-hair
-fingerprints

4

Where is thick skin found? 5

Palms of hands and soles of feet

5

How is contact between the epidermis and dermis maintained? 6

Via heme desmosomes @ the dermal-epidermal junction

6

What does the epidermal-dermal border follow? 6

The dermal ridge follows the dermal papilla

7

What cells are found in the epidermis? 8

Keratinocytes
Melanocytes
Merkel Cells
Langerhans cells

Killed My Mom's Lover

8

What are the layers of the epidermis from most superficial to deep? 8

Stratum corneum
Stratum lucidum
Stratum granulosum
Stratum spinosum
Stratum basale (germantivum)

Cat Loves Gay Super-fly Boys

9

What is the main problem in psoriasis?

High rate of turnover in skin reproduction

10

What is the keratin precursor and where is it produced? 9

Cytokeratin produced by Startum Spinosum

11

What are aggregates of cytokeratin called? 9

Tonofillaments

12

What is the malpghian layer? 9

Stratum spinosum + stratum basal

13

What two granules are contained within the Stratum Granulosum? 10

Keratohyalin granules

Lamellar granules

14

What is the role of Keratohyalin granules? 10

Assembles keratin into bundles

(Cys and His rich)

15

What is the role of Lamellar Granules? 10

Form a lipid-rich (waterproof) barrier to foreign material (and water loss)

16

What is the composition of the Stratum Lucidum? 11

Densely packed keratin filaments with no organelles or nuclei

Translucent

17

What is the main component of
Stratum Corneum? 12

Squares - fully keratinzed cells

18

What is the function of keratinocytes? 14

Produces keratin & lamellar granules

Stores melanin

19

What is the function of melanocytes? 15

Produces melanin (that is then stored in keratinocytes)

20

What enzyme produces melanin? 16

Tyrosinase enzyme:

Converts tyrosine --> DOPA

21

What is DOPA? 16

A monomer of melanin

22

What is the function of Langerhan cells? 17

Site-specific macrophages APCs that leave the cell once activated by an Ag

23

What is the function of Merkel cells? Where are they found? 19

Found in the Stratum Basale

Light touch & texture

24

What two layers make up the dermis? 19

Papillary layer

Reticular layer


Dermis is avascular

25

What is contained within the Papillary Dermis? 20

Meissner corpuscles

Dermal Papillar

26

What is contained within the Reticular Dermis? 20

Type I collagen

Elastic fibers

27

What two plexi do we find in the dermal layer? 20

Subpapillary plexus

Cutaneous plexus - main feeder

28

Where are adipocytes stored within the skin? 21

Within the hypodermis (subcutaneous) layer

29

What is the role of Free Nerve endings? Where are they located? 23

Pain (itching and temperature)

Found along the dermal-epidermal junction

30

What is the role of Meissner Corpuscles? Where are they located? 24

Detect light touch or low frequency stimuli

Found in dermal papillae (fingertips, palms)

31

What is the role of Pacinian Corpuscles? Where are they found? 25

Coarse touch, vibration, or pressure

Found in the dermis or hypodermis

32

What is the role of Merkel Disks? 25

High resolution tactile receptor

33

What characterizes Sweat (Sudoriferous) glands? What kind of epithelium? 27, 29

A coiled eccrine (merocrine) or apocrine gland

Epithelium - cuboidal

34

What is the role of Apocrine glands? What type of secretion? 31

A type of sudorfierous sweat gland

Utilizes merocrine (milky) secretion

35

What two types of stimuli do Apocrine glands respond to? 30

Adrenergic Regulation (sympathetic)

Hormones

36

What is the role of Sebaceous glands and what is their product? 28

Lubricates hair and skin

Product - sebum

37

What are the three layers of the hair shaft? 32

Outside --> in

Cuticle --> cortex --> medulla

38

What is the lunula of the nail? 33

Crescent-shaped white area near nail matrix