Primer To Immunology - Bowden Flashcards Preview

HDM - Midterm > Primer To Immunology - Bowden > Flashcards

Flashcards in Primer To Immunology - Bowden Deck (22):
1

What cells make up the innate immunity?

Mast Cells (Both)

Phagocytes

Dendritic Cells (Both)

NK cells

Complement

Basophils (both)

Neutrophils

Eosinophils

2

Active and passive immunizations are making changes to what part of the immune system?

The adaptive immune system

3

What is an example of passive immunity? Does passive immunity have specificity/memory?

Injection of antibodies

- specificity, but no memory

4

What's an example of active immunity? Does it have specificity and memory?

Infection or Ag introduction via vaccine

Has both specificity and memory

5

What lineage do the cells of our innate immune originate from?

Myeloid lineage

CFU-HM --> monocytes & neutrophils

6

What is the major cytokine stimulating production of eosinophils?

IL-5

7

What is the major cytokine stimulating production of Basophils? What cytokine produces its precursor?

Main cytokine --> IL-4

Basophilic Myeloblast precursor --> IL-3

8

Besides Mast cells what cell plays a major role in atopic or allergic response?

Eosinophils - they sustain the allergic response

9

What is the major granule within Mast Cells and Basophils?

Mast Cells --> Histamine

Basophils --> Heparin > histamine

10

What cytokines are produced by Mast Cells?

IL-1 (hematopoiesis)
IL-5 (activates eosinophils)
IL-3, 4, 6, 8

11

What is the CD marker for Mast Cells?

CD23

12

What cytokines activate Natural Killer cells?

IL-12 (from macrophages)

IL-15

type I IFNs

13

What is the CD marker for Natural Killer Cells?

CD16

CD56

14

What do Natural Killer cells secrete and what is its function?

IFN-γ --> activates macrophages

15

What is clonal expansion? 29

Increasing the number of Ag-specific lymphocytes from naive lymphocytes

16

What is the humoral immunity?

B cells and antibodies

17

What is cell-mediated immunity?

T lymphocytes

18

What extracellular component is a major component of our immune system?

Commensal bacteria

19

How does the vagina avoid infection?

metabolism of glycogen by the bacteria L. Acidophilus lowers the pH to 5

20

What are sites of primary immune sites?

bone marrow

Thymus

21

What are secondary immune sites?

Spleen

Lymph Nodes

Mucosal immune tissue (MALT & GALT)

22

What's the difference between basophils and mast cells in terms of circulation?

Mast cells are never found in circulation (tissue only)

Basophils are predominantly found in circulation