Primer To Immunology - Bowden Flashcards
(22 cards)
What cells make up the innate immunity?
Mast Cells (Both)
Phagocytes
Dendritic Cells (Both)
NK cells
Complement
Basophils (both)
Neutrophils
Eosinophils
Active and passive immunizations are making changes to what part of the immune system?
The adaptive immune system
What is an example of passive immunity? Does passive immunity have specificity/memory?
Injection of antibodies
- specificity, but no memory
What’s an example of active immunity? Does it have specificity and memory?
Infection or Ag introduction via vaccine
Has both specificity and memory
What lineage do the cells of our innate immune originate from?
Myeloid lineage
CFU-HM –> monocytes & neutrophils
What is the major cytokine stimulating production of eosinophils?
IL-5
What is the major cytokine stimulating production of Basophils? What cytokine produces its precursor?
Main cytokine –> IL-4
Basophilic Myeloblast precursor –> IL-3
Besides Mast cells what cell plays a major role in atopic or allergic response?
Eosinophils - they sustain the allergic response
What is the major granule within Mast Cells and Basophils?
Mast Cells –> Histamine
Basophils –> Heparin > histamine
What cytokines are produced by Mast Cells?
IL-1 (hematopoiesis)
IL-5 (activates eosinophils)
IL-3, 4, 6, 8
What is the CD marker for Mast Cells?
CD23
What cytokines activate Natural Killer cells?
IL-12 (from macrophages)
IL-15
type I IFNs
What is the CD marker for Natural Killer Cells?
CD16
CD56
What do Natural Killer cells secrete and what is its function?
IFN-γ –> activates macrophages
What is clonal expansion? 29
Increasing the number of Ag-specific lymphocytes from naive lymphocytes
What is the humoral immunity?
B cells and antibodies
What is cell-mediated immunity?
T lymphocytes
What extracellular component is a major component of our immune system?
Commensal bacteria
How does the vagina avoid infection?
metabolism of glycogen by the bacteria L. Acidophilus lowers the pH to 5
What are sites of primary immune sites?
bone marrow
Thymus
What are secondary immune sites?
Spleen
Lymph Nodes
Mucosal immune tissue (MALT & GALT)
What’s the difference between basophils and mast cells in terms of circulation?
Mast cells are never found in circulation (tissue only)
Basophils are predominantly found in circulation
