intro to immune system Flashcards
types of immunity
innate
adaptive
where are leukocytes derived from
haemocytoblasts
what control the pathway the cell differentiated to
colony stimulating factors
name all the WBCs
neutrophils basophils esinophils moncytes lympocytes
name mononuclear leukocytes
moncyte
T cells
B cells
where do cells differentiate
bone marrow
what do neutrophils do
express receptors for antibodies and complment
kill microbes by secreting toxic substances
what do esinopils do
granules have major basic protein which activates neutrophils
what do basophils do
express IgE
involved in allergic reactions
what do monocytes do in tissues
differentiate into macrophages
where do T cells mature
Thymus
where are mast cells found and involved in
tissues
allergic reactions
where are natural killer cells found and involved in
spleen/tissues
viral infected cells
dendritic cells site
reside in skin migrate to lymph nodes once activates
soluble factors
complment
antibodies
cytokines
chemokines
what are complement and what do they do
inactive serum proteins
direct lysis
coat invading organisms
what do antibodies/immunoglobulins do
bind to antigens
types of cytokines
interferons interleukins colony stimulating factors chemokines tumour necrosis factors
what do chemokines do
direct leukocyte movement from blood to tissues
what do tumour nercrosis factors do
mediate inflammation and cytotoxic reactions
what do CSF do
direct differentiation of bone marrow stem cells
what do inerkuekins do
pro or anti-inflammatory
dive cell division/differentiation
what do interferons do
stop viral spread
activate T cells
regions of immuoglobulin
Fab
Fc
