iron absorption and metabolism (anaemia) Flashcards
Iron has two ionic states:
Fe2+ → Fe???
Ferrous → Ferric
(reduced) → (oxidised)
Fe3+
For absorption, non-haem iron needs to be in the reduced
or oxidised state? (role of vit. C)
reduced state Fe2+
Once absorbed by intestinal cell, Fe2+ → Fe3+ for transport of iron in ??? where caeruloplasmin (ferroxidase) is the enzyme responsible and Cu is the coenzyme
transferrin
Haem iron includes: haemoglobin and ???
myoglobin
haemoglobin & myoglobin
Source: Meats, fish
Intake/d: 1-2mg iron (10-15%)
Absorption: approx 25%
Iron status: ???
Cooking: haem → nonhaem (as iron has left the haemoglobin molecule)
unaffected
non haem iron is called: ???
elemental iron
elemental iron
Source: cereals, vegetables
Intake/d: main form of dietary iron (85-90%)
Absorption: 10-15%
—-> depends on composition of
meal (bioavailability) (35%
growth)
Iron status: ???
affected
what is iron recycled into?
synthesis of haemoglobin
where is iron stored?
spleen
TRUE or FALSE: haeme is converted into bilirubin in the spleen, liver, bone marrow and stored in liver to be secreted with bile
TRUE
how many g of iron does the body contain?
5g
what percentage of iron is boudn to haemoglobin?
70%
Iron is stored by being bound to ??? as haemosiderin
ferritin
approx how much iron is lost per day? (due to: urine, faeces and
shed cells)
1mg
Menstrual cycle losses approx ???mg per month
20mg
