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Flashcards in Jaundice Deck (16):
1

Unconjugated hyperbilirubinemia in a person without jaundice or known underlying hepatic dysfunction

Gilbert syndrome

congenital reduction of bilirubin conjugation in the liver (AR)

2

Red cell fragments on smear; unconjugated hyperbilirubinemia

hemolysis

3

In hemolysis, what is elevated besides bilirubin (unconjugated)

serum LDH and haptoglobin

4

jaundice, fever, fatigue, malaise, vomiting, anorexia, RUQ pain, clay colored stools

Hep A

5

Bad complications of chronic Hep B

cirrhosis and HEPATOCELLULAR CARCINOMA!!!! (responsible for 80% of hepatocell carc worldwide)

6

HbsAG

hepatitis b surface antigen
present in both acute and chronic infection.
detectable 1-10 weeks, peaks then disappears by 4-6 months

7

antiHBs

antibody to surface antigen
when seen without HbSAg, this means infection has resolved or patient got the vaccine

8

IGM anti HbC

hepB core antigen
presence = ACUTE INFECTION

when you only see surface antigen without HbcAg, it means you have chronic hep B

9

Treatment for Hep A and B

supportive care and symptomatic treatment; hospitalize if extensive liver damage

vaccines also recommended for children and high risk adults (travel, exposure, IV drug users, chronic liver dx)

10

most common cause of chronic liver dx in US

hep C; most prevalently affects those born between 1945 - 1965

11

Of those dx with hep C, _____% will develop chronic infection

60-80%

12

long term complications of chronic hep C

cirrhosis, hepatocellular carcinoma, hepatic decomp

13

Current leading cause for liver transplantation in the US

chronic hep C

14

Possible treatment for hep C

ribavirin and/or interferon

15

AST TO ALT ratio on alcohol abuse

>2:1, with elevated GGT

16

Post hepatic causes of hyperbilirubinemia

obstruction of bile (gall stones, pancreatic cancer, biliary disease)