L14-15: Protein Structure and Function Flashcards Preview

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Flashcards in L14-15: Protein Structure and Function Deck (21)
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1
Q

how are amino acids categorised 4 groups

A
polar 
unpolar 
- acidic 
- basic 
- uncharged
2
Q

what is involved in the peptide bond joining aa

A

not side chains

b/w N and C terminus

3
Q

are polypeptides flexible

A

not flex about peptide bond

but flexi about inter

4
Q

what restricts conformations of polypeptides

A

non covalent bonding

5
Q

explain proteins hydrophobic interactions when determine protein confirmation

A

hydrphobic core = nonpolar stay on inside

polar side chains stay on outside forming h bonds with water

6
Q

what acts as stabilising bonds in some protein confirmations

A

disulphide bonds

7
Q

what are the two folding motifs of 2ndary structures

A

a helix

beta pleated sheets

8
Q

explain a helix structure

A

Carbonyl oxygen of peptide bond = hydrogen bonded to amid hydrogen of amino acid 4 residues away

9
Q

explain b sheets structure

A

laterally packed b strand (parallel or anti)

10
Q

what secondary structure is in transmembrane proteins

A

a helix

11
Q

what is a protein domain

A

region of polypeptide that can fold independly into stable structure

12
Q

as an organisms increases in complexity, what happens to number of domains

A

increases

13
Q

what ligands do antibodies bind and what is the result

A

antigens= destruction

14
Q

what are keratin monomers

A

fibrous proteins= assemble into intermediate filaments

15
Q

function of enzymes protease

A

hydrolyse peptide bonds b/w aa

16
Q

function of enzymes polymerase

A

catalyse polymerisation such as synthesis of DNA.RNA

17
Q

function of enzymes kinase

A

catalyse addition of phosphate groups to molecules

18
Q

function of enzymes phophatase

A

catalyse hydrolytic removal of phosphate group from molecule

19
Q

two ways enzymes are regulated

A

by binding other molecules

by phosphorylation

20
Q

how does motor proteins generate movement

A

movement coupled with hydrolysis of ATP

21
Q

what is the movement of kinesis and dynein

A

move cytoplasmic components (cargo) along microtubules

atp hydrolysis occurs at head regions