L14-15: Protein Structure and Function Flashcards Preview

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Flashcards in L14-15: Protein Structure and Function Deck (21)
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1

how are amino acids categorised 4 groups

polar
unpolar
- acidic
- basic
- uncharged

2

what is involved in the peptide bond joining aa

not side chains
b/w N and C terminus

3

are polypeptides flexible

not flex about peptide bond
but flexi about inter

4

what restricts conformations of polypeptides

non covalent bonding

5

explain proteins hydrophobic interactions when determine protein confirmation

hydrphobic core = nonpolar stay on inside
polar side chains stay on outside forming h bonds with water

6

what acts as stabilising bonds in some protein confirmations

disulphide bonds

7

what are the two folding motifs of 2ndary structures

a helix
beta pleated sheets

8

explain a helix structure

Carbonyl oxygen of peptide bond = hydrogen bonded to amid hydrogen of amino acid 4 residues away

9

explain b sheets structure

laterally packed b strand (parallel or anti)

10

what secondary structure is in transmembrane proteins

a helix

11

what is a protein domain

region of polypeptide that can fold independly into stable structure

12

as an organisms increases in complexity, what happens to number of domains

increases

13

what ligands do antibodies bind and what is the result

antigens= destruction

14

what are keratin monomers

fibrous proteins= assemble into intermediate filaments

15

function of enzymes protease

hydrolyse peptide bonds b/w aa

16

function of enzymes polymerase

catalyse polymerisation such as synthesis of DNA.RNA

17

function of enzymes kinase

catalyse addition of phosphate groups to molecules

18

function of enzymes phophatase

catalyse hydrolytic removal of phosphate group from molecule

19

two ways enzymes are regulated

by binding other molecules
by phosphorylation

20

how does motor proteins generate movement

movement coupled with hydrolysis of ATP

21

what is the movement of kinesis and dynein

move cytoplasmic components (cargo) along microtubules
atp hydrolysis occurs at head regions