L23-24: Regulation in Eukaryotes Flashcards Preview

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Flashcards in L23-24: Regulation in Eukaryotes Deck (10)
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1

diff b/w housekeeping. facultative , inducible genes

HK= essential
F= only expressed the required
I= expression response to changes

2

what is chromatin

dna packaged around histone (have positive aa)

3

what does histone having positive charged aa do

an interact strongly with the negative charges of the phosphate groups in DNA

4

explain acetylation of histone

adds (HATs) negative charge to aa = neutralises > activated

5

what are chromatin remodelling complexes

alter chromatin structure w/out changing histone chemistry
- bind directly to DNA + reposition nucleotides so DNA= accessible

6

what does gene methylation do and an example

gene silencing
- CpG methylation

7

protein coding trascnoprtoin control regions


---- promotor proximal elements
-----distal promotor elelements (enhancer or repressor)

8

difference b/w cis elements and trans acting factors

cis= acting on same molecule
trans= different

9

what is morphogen

non uniform distributed signalling molecule regulating pattern during differentiation

10

what are transcription factor proteins and their roles

determine if gene is on/off
- have a DNA binding domain
- single sensing domain (sad)
transactivation domain