l16 Flashcards

1
Q

first synapse release what to what receptors

A

Acetylcholine to nicotinic receptors

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2
Q

Nicotine is agonists or antagonists nicotinic receptors are what channel

A

agonist
- ligand gated channel
- direct

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3
Q

cholinergic receptors

A

receive acetycholine
can b g coupled or ligand gated

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4
Q

parasympathetic second synapse release what to what

A

acetycholyne to muscurania receptors

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5
Q

muscarinic receptors

A

muscarine is agonist
- receptor is g coupled channels
- activate second messenger

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6
Q

sympathetic second synapse release what to what

A

noradrenaline to adrenergic receptors

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7
Q

adrenergic receptors

A

a class of g coupled
- receive norepinephrine (noradrenaline) and epinephrine (adrenaline).

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8
Q

a1 adrenoreceptor excitatory

A

Smooth muscle:
vascular
genitunary (sphincter, urinary bladder)
heart
liver
eyes
CNS post synaptic neuron
saliva

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9
Q

a1 adrenoreceptor inhibitory

A

smooth muscle intestinal

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10
Q

a2 adreno receptor inhibitory

A

pre + post synaptic neuron, cns and

-> pancreas platelets

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11
Q

b1 excitatory adreno

A

cns post synaptic
intestinal
heart
rena juxtaglomarular (regulate blood pressure - blood vessel)

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12
Q

b2 excitatory adreno

A

cns post-synaptic, intestinal, bronchial, skeletal mus vascula bed + skeletal mus liver eyes (cililary muscle) mast cell, blood vessel, detrusor muscle (urinary)

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13
Q

b3 excitatory adreno

A

adipose tissue

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14
Q

sympathetic innervation: tissue influenced by a1 + effects:

A

eye iris (contract radial muscle)
saliva gland (release k+)
blood vessel (contraction constriction of vascular muscle in skin, mucosa, abdominal)
gastrointestinal (contraction - sphincter)
urinary bladder (contraction - sphincter)

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15
Q

sympathetic innervation: tissue influenced by b1 + effects:

A

salivary (amylase secretion)
heart (increase contraction sa node, automaticity av node)

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16
Q

sympathetic innervation: tissue influenced by b2 + effects:

A

eye ciliary muscle (relax far vision)
bronchi (relax/dilation smooth muscle)
blood vessel (dilation coronary vessel, vasculature in skeletal muscle bed)
gastrointestinal tract (relax sphincter)
urinary bladder (relax detrusor)
skeletal muscle (tremor, glycogenolysis)
mast cell (inhibition of histamine release)

17
Q

sympathomemtic

A

insomnia
restlestness
tremor
palpitation
tachyrcardia

18
Q

adrenergic agonist