L4-BCMB2002_tertiary-Gooley

Question 1

Van der Waal contacts

Answer 1

How close atoms can pack

Question 2

What did Anfinsen experiment convince people of?

Answer 2

That a acid sequence determined 3-D structure of a protein

Question 3

VDW radius of C is ___ and H is ___

Answer 3

1.7 A, 1.1 A

Question 4

VDW distance b/n 2 C is __ and 2 H is __

Answer 4

4A, 2A

Question 5

VDW: -ve E is ___

Answer 5

favourable

Question 6

VDW: contact distance is the ____

Answer 6

minimum Rm

Question 7

Hydrogen bond:

Answer 7

electrostatic attraction that occurs when two electronegative atoms compete for the same hydrogen atom. In cases of A.acids, N is donor and O is acceptor

Question 8

N-H distance is ___, expected donor-acceptor distance is __

Answer 8

2.9 A, 3.1 A

Question 9

___ A are strong mostly covalent bonds

Answer 9

2.2-2.5 A

Question 10

___ A are moderate and mostly electrostatic

Answer 10

2.5-3.2 A

Question 11

___A are weak and electrostatic

Answer 11

3.2-4.0 A

Question 12

Any polar group buried in the protein MUST form ____

Answer 12

hydrogen bond - includes charged groups (but these are rarely buried)