L5 & 6 Flashcards
(27 cards)
Any buried protein group in a protein must be ?
H-bonded
a-helix is ___ handed
Right
a-helix has ___ res per turn
3.6
a-helix has ___ A per turn
5.4
a-helix has ___ A axial rise per residue
1.5
a-helix phi psi
-57, -47
B-sheet is formed from B _______
Strands
B-sheet phi psi
-130, +130
B-sheet, every second residue is ____-
hydrophobic
Reverse turn is mostly found ____
on surface
Reverse turn has _ residues
4
Reverse turn residue __ and __ have different phi psi angles
i+1, i+2
H bond between NH of (____) and the carbonyl of (_) stabilises the turn
i+3, i
Proline often in position ___ because?
i+1, phi angle -60 matches B turn requirement
Type 2 turns have ___ in i+2 because?
Gly, lack of steric hindrance
Type I and 2 differ by ?
Direction of i+1 carbonyl
Regular structures are?
Residues with repeating phi psi angles
Irregular structures are?
Often linking regular elements and is termed “loop structure”
Pri, sec, tert, quart
AA sequence, sequence into elements, elements into domains, multiple chains
What is a domain?
Region within the native tertiary structure for which evidence can be provided of an existence independent of the rest of the protein.
What does modular mean in regards to domains?
Repeating domains
3 super sec structural elements
aa hairpin, bb hairpin, bab
Intragenic mutation
point mutations
Gene duplication
whole/part duplicated
