[LEC] Inflammation Flashcards
Protective response that initiates the process of repair involving host cells, blood vessels, proteins, and other mediators
Inflammation
Enumerate the cardinal signs.
- Tumor – swelling
- Rubor - redness
- Calor – heat
- Dolor – pain
- Functio Laesa - loss of function
What is the hallmark of acute inflammation?
presence of neutrophils
What will happen if the fluid leak through blood vessels?
edema
Enumerate the 2 components of acute inflammation.
- Vascular changes
- Cellular events
What is the most common cause of inflammation?
Infection
Identify the stimuli.
- blunt and penetrating
Trauma
Identify the stimuli.
- against environmental substances or against “self” tissues
- “immune-mediated inflammatory disease”
Immune reactions
Enumerate the process of leukocyte recruitment.
- loose attachment to and rolling on endothelium (mediated by selectin)
- firm attachment to the endothelium (mediated by integrins)
- migration through interendothelial spaces
What mediates the loose attachment to and rolling on endothelium of leukocyte?
selectin
What mediates the firm attachment to the endothelium of leukocytes?
integrins
What increases the avidity of integrins for their ligands and promotes the directional migration of leukocytes?
Tumor Necrosis Factor (TNF) and IL-1
Identify the morphologic pattern.
- an outpouring of a watery and relatively protein-poor fluid
serous
Identify the morphologic pattern.
- consequence of more severe injuries
- result in greater vascular permeability that allows large molecules (such as fibrinogen) to pass the endothelial barrier
Fibrinous
Identify the morphologic pattern.
- Appears as an eosinophilic meshwork of threads or sometimes as an amorphous coagulum
Fibrinous
