Lecture 11 - Antidepressants Flashcards Preview

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Flashcards in Lecture 11 - Antidepressants Deck (71)
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61

Major draw back of using mirtazapine?

weight gain

IMPORTANT POINT

62

Mechanism of Buproprion

largely unknown!
-does not inhibit NE or serotonin reuptake
-weakly blocks dopamine reuptake
-mild stimulant - treats comorbid fatigue/poor concentration, ADHD
-low affinity for muscarinic, alpha 1 adrenergic or histaminergic receptors

63

Adverse effects of buproprion

-much lower incidence than TCAs
-can include nausea, headache, dizziness, insomnia, seizures

**no sexual dysfunction or weight gain or sedation

64

Drug interactions with bupropion

-meds that lower seizure threshold, L-dopa
-CYP 2D6 inhibitor

65

Advantages of bupropion

-as tolerable as SSRIs
-stimulant effects may be helpful
-may offer relief from SSRI or SNRI-induced sexual dysfunction or weight gain

66

Examples of monoamine oxidase inhibitors (MAOIs)

phenelzineu
moclobemide
tranylcypromine

67

explain the mechanism of MAOIs

MAO-A breaks down NE and serotonin

MAO-B breaks down dopamine

we are inhibiting these so therefore we would increase NE, serotonin, and dopamine

68

When would you use MAOIs?

they are usually reserved for patients unresponsive to other therapies due to side effects and drug and food interactions

*def not 1st line treatment

69

Adverse effects of MAOIs

-orthostatic hypotension
-antimuscarinic
-mild-moderate sedation
-dose-related sexual dysfunction in males and females
-hypertensive crisis

70

see slide 28

kay man

71

What 2 types of antidepressants are first line therapies?

SSRI
SNRI