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Tissue Engineering and Regenerative Medicine > Lecture 13 > Flashcards

Lecture 13 Flashcards

1
Q

What are the different methods of potentially reprogramming a fibroblast into a cardiomyocyte?

A

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2
Q

What is a master regulator? What are the master regulators of reprograming?

A

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3
Q

What were the candidate TFs which were come up with? What were their properties?

A

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4
Q

What is a reporter system? What was the reporter system used to identify CMs?

A

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5
Q

Were they able to directly programme fibroblasts into CMs? What was the problem?

A

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6
Q

What did they do to try and solve this problem?

A

dewsaads

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7
Q

What were the final 4 factors? What was the efficiency?

A

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8
Q

How did they narrow down the factors even more? What was the experiment?

A

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9
Q

What other genes are also cardiac specific?

A

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10
Q

What are iCMs?

A

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11
Q

What experiment has been done to show that the iCMs were actually CMs?

A

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12
Q

What showed that the iCMs has functional properties?

A

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13
Q

What showed whether the iCMs could integrate?

A

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14
Q

Can you reprogram fibroblasts in vivo? How? What was the experiment done?

A

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15
Q

What is the reporter system used to track the lineage of CM to see whether they came from CF?

A

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16
Q

What were the results which showed that it was possible to reprogram in vivo CF –> CM? What showed it?

A

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17
Q

What were the properties of the reprogrammed cells? What did this show?

A

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18
Q

What about other cell types? What is the difference when looking at motor neurons?

A

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19
Q

How did they reprogram fibroblasts to neurons? What were the stages?

A

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20
Q

How did they pick the master regulators? What was the reporter system?

A

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21
Q

How did they introduce the 19 TFs? What happened after introducing the TFs?

A

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22
Q

How did they narrow down the candidate TFs? How was this method different? What was the final combination?

A

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23
Q

What were the properties of the resulting iNeurons?

A

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24
Q

What cell cannot turn into iN?

A

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25
Q

Why can keratinocytes not be reprogrammed?

A

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26
Q

What is the trivalent histone state? What is the importance of it in reprogramming? What cells have it? What cells do not have it?

A

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Tissue Engineering and Regenerative Medicine (17 decks)

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