Lecture 14

Question 1

What is the current drug development process? What is tested at each stage?

Answer 1

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Question 2

What are the drugs tested on?

Answer 2

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Question 3

What is the problem with the drug development process? What does this show? What are you losing out on?

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Question 4

If a drug is repackaged what is different about the clinical trials process?

Answer 4

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Question 5

What would be a new way of drug development that would help assess toxicity?

Answer 5

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Question 6

What is the DARPA initiative? When was it? What did they want?

Answer 6

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Question 7

What would be the use of the organ-on-chip system? What would be the benefit of creating a whole system in comparison to just one organ on a chip?

Answer 7

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Question 8

What were the two types of organ-on -chip systems which was created?

Answer 8

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Question 9

What was the NCAT initiative? What was different about this organ-on-chip system?

Answer 9

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Question 10

What is the cardio-pulmonary system? What is needed to be mimicked?

Answer 10

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Question 11

What is the function of a lung? What is the cellular structure and properties?

Answer 11

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Question 12

What is the criteria for the tissue when making a lung on chip? What is the criteria for the chip?

Answer 12

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Question 13

What was the lung on chip design structure?

Answer 13

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Question 14

What were the cells which were grown on different layers? What were the signals given to the structure?

Answer 14

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Question 15

What happened as a results of the air interface? What other features developed making the system resemble alveoli?

Answer 15

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Question 16

What is a normal phenomenon which happens in inhalation in the lungs? How was this replicated in the lung on chip design?

Answer 16

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Question 17

What physiological response was replicated in the lung on chip system?

Answer 17

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Question 18

What is pulmonary inflammation?

Answer 18

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Question 19

How was this replicated in the lung on chip system?

Answer 19

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Question 20

What was another way to show pulmonary inflammation response in the lung on chip system? What was found to improve this response?

Answer 20

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Question 21

How was oedema promoted in the lung on chip system?

Answer 21

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Question 22

What is the criteria for the tissue and chip for a heart on a chip?

Answer 22

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Question 23

How is the cardiac tissue aligned in the body? How is it aligned in culture? What is the consequence of this difference in alignment?

Answer 23

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Question 24

What is the design of the heart on a chip? How do they get the cells onto the chip? How to they get the cells to stick on? How do the cardiomyocytes align?

Answer 24

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Question 25

How were the cells made into chips which had contractility? What did the different states represent?

Answer 25

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Question 26

What did each film represent?

Answer 26

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Question 27

Define Systole? Define Diastole?

Answer 27

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Question 28

How did the architecture and alignment change with different fibronectin properties?

Answer 28

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Question 29

What is a consequence of an isotropic cellular alignment?

Answer 29

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Question 30

What is the heart on a chip’s response to adrenaline?

Answer 30

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Question 31

What is the goal now with the lung and heart chips?

Answer 31

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Question 32

What can be done with this in the future?

Answer 32

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