Lecture 19 and 20 Flashcards
How is inflammation in the liver classified
- Distribution
- Atomical area affected
- Typer of inflammatory cells
- Duration
- Severity
- Causative agent
What is non-specific teactive hepatitis
- Often diffuse throughout liver around portal tracts
- Response to systemic illness
- GIT disturbances/infections
- Redidual prior hepatic health
- Acute haemorrhagic pancreatitis
- Often an incidentalding
Non-specific reactive hepatitis
What is seen with Canine chrinic hepatitis
- Cause often undetermined
- Hereditary copper toxicosis and hepatitis
- Other familial chronic hepatitis
- Liver is often small/shrunken/nodualr
- Inflammatin and fibrosis
- Intrahepatic cholestasis
Canine chronic active hepatitis
Canine chrinic active hepatitis
Whats is cholangitis
Inflammation limited to the biliary ducts in portal area
What is cholangiohepatitis
Inflammation centred on ducts but has spilled out and involves the periportal area
Suppurative cholangitis
Feline lymphocytic cholangitis
Feline Lymphocytic Cholangiohepatitis
Chronic Cholangitis
What causes bacteraemia, septicaemia
Bacterial nfections that have sustained or repeated bacteraemic phace foften produce liver lesions
What can septicaemia produce
- Multifocal necrosis and inflammation or small aggregations of inflammatory cells
How do infections of the portal vein occur
Some enteric bacteria may enter the portal blood stream and gain entry to the liver
- In liver bacteria may be phagotosed by Kupffer cells
- Such bacteria may proliferate in the liver and cause local lesions or bacteraemic phase
Haematogenous infectious agents often cause multifocal random hepatic necrosis
How does CAV1 spread
Oral route
What does CAV1 target
Endothelial cells, hepatocytesm renal epithelium
- Enarged liver with fibrin surface
- Acute hepatic nectosis and inflammation
- Widespread petechial haemorrhages
- Excessperitoneal fluid
Infectious canine hepatitis
Infectious canine hepatitis: necrosis and intranuclear viral inclusion bodies
Where is herpes virus common
Foetuses and neonates
Equine herpesvir1
Hepatitis/hepatic necrosis in foal
What is Theiler’s disease
- Equine serum hepatitis
- Sporadic form of acute liver failure and death in horses
- Many occur in horses that have recieved injection of agent containing equine serum
Clinical signs and pathology of Theiler’s disease
- Hepatoencephalopathy
- Janundice and dark urine
- Flabby ‘ dishrag’ liver
- Secere periaciner and midzonal hepatocellular necrosis and harmorrhage
