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Psychopharmacology > Lecture 21: NSAIDs > Flashcards

Lecture 21: NSAIDs Flashcards

1
Q

NSAID stands for

A

non-narcotic, non-steroidal, anti inflammatory analgesics

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2
Q

4 chronic pain treatment options

A
  1. NSAIDs
  2. antidepressants with NE potentiation action
  3. anticonvulsants
  4. opioid analgesics
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3
Q

NSAID MoA

A

inhib synthesis and release of prostaglandins, body hormones that produce local inflammatory response

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4
Q

NSAIDs are chemically ___

A

unrelated

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5
Q

NSAIDs inhibit the enzyme ___

A

cyclooxygenase (COX)

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6
Q

COX converts __ to ___

A

arachidonic acid to prostaglandins

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7
Q

COX-1 mediates production of prostaglandins that __ and __

A
  1. protect GI tract

2. allow normal platelet functioning in blood clotting

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8
Q

COX-2

A

inducible enzyme; induced in response to inflammation

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9
Q

COX-2 is increased in __ and __ in response to immune instigators

A
  1. spinal cord

2. peripheral tissues

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10
Q

MoA of aspirin for fever

A

inhibition of prostaglandin synthesis in hypothalamus, with modulates body temperature

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11
Q

5 effects of inhibiting COX1 and COX2

A
  1. anti inflammatory
  2. anti pyretic
  3. analgesic
  4. inhib platelet aggression
  5. adverse GI effects
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12
Q

tylenol is ___ effective than aspiring at reducing inflammation

A

less

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13
Q

three effects acetaminophen has but aspiring does not

A
  1. does not inhibit platelet function
  2. does not lead to Reye’s syndrome
  3. causes less GI distress
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14
Q

ibuprofen __ inhibit platelet aggregation

A

does

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15
Q

ibuprofen is __ tolerated than aspirin

A

better

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16
Q

COX2 inhibitors may reduce __

A

the risk of cancer

17
Q

COX2 selective inhibitors provide some of the benefits of aspirin while reducing the rate of __

A

gastric ulcers

18
Q

the only available selective COX2 inhibitor

A

celebrex (celecoxib)

19
Q

does celebrex inhibit platelet aggregation? what is the effect?

A

no; might increase incidence of heart attack and stroke

20
Q

nitroaspirings

A

NO bound to NSAID via ester linkage

Psychopharmacology (22 decks)

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