Lecture 22: Blood and Hematopoiesis Flashcards Preview

First Semester: Microscopic Anatomy > Lecture 22: Blood and Hematopoiesis > Flashcards

Flashcards in Lecture 22: Blood and Hematopoiesis Deck (86)
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1

Three functions of whole blood

1. Transport
2. Temperature regulation
3. Water balance

2

Whole blood is what percent total body weight

5-10%

3

Whole blood is comprised of

60% of plasma (water, solutes)
40% formed elements (RBC, WBC, PLT)

4

Plasma composition

90% water
8% proteins
2% other solutes

5

Plasma is found.., unlike serum

in vasculature

6

Serum lacks..., unlike plasma

coagulation proteins (fibrinogen)

7

Plasma tubes

anticoagulant tubes - blood does not clot

8

Serum tubes

serum separators - blood is allowed to clot

9

Examples of plasma tubes

EDTA - purple
Heparin - green
Citrate - blue

10

Examples of serum tubes

Red top
Marble top

11

Daily output of RBC

2.5 billion

12

Daily output of WBC

1.0 billion

13

Daily output of PLT

2.5 billion

14

Most numerous formed element in blood

RBC (measured in millions, versus WBC and PLT measured in thousands)

15

Two functions of RBC

-Carry O2 to tissue and CO2 to lungs
-Involved in acid-base homeostasis

16

Shape of erthrocytes

-Biconcave disc
-Flexible membrane
-High SA-V ration

17

Mean cell volume is measured in

femtoliters (fL)

18

Lifespan of RBC is roughly proportional to

body size

19

Polychromatophils

-RBCs that are 1 stage back in development
-Normal finding in low numbers in some species
-Larger than mature RBC, smaller than neutrophil
-Round to amorphous
-Amphophilic color

20

Nucleated erythrocytes in mammals

-Abnormal finding associated with pathology
-Ex: Regenerative anemia, bone marrow damage, diseases affecting RBC maturation, damage to spleen/asplenia, some toxins

21

Least numerous formed element in the blood

Leukocytes

22

Function of leukocytes

Inflammation and the immune response

23

Two major categories of leukocytes based on developmental process

1. Myeloid
2. Lymphoid

24

Four myeloid leukocytes

-Neutrophils
-Eosinophils
-Basophils
-Monocytes

25

Lymphoid leukocytes

lymphocytes

26

Most numerous WBC

neutrophil

27

Function of neutrophils

-Innate immunity
-Phagocytic and killing cells
-Granules contain antibacterial substances

28

Neutrophil staining

-Nucleus: segmented with dense violet chromatin
-Cytoplasm: pale-staining, neutral

29

Heterophil staining

-Nucleus: segmented with dense violet chromatin
-Cytoplasm: red, rice-shaped granules

30

Band neutrophils

-Rare bands are normal blood smear findings in some species
-One stage less than mature segmented neutrophil