lecture 23

Question 1

describe spontaneous mutations - strand slippage during replication

Answer 1

a

Question 2

describe spontaneous mutations - strand slippage during replication - insertion

Answer 2

a

Question 3

describe spontaneous mutations - strand slippage during replication - deletion

Answer 3

a

Question 4

what is cause of many trinucleotide repeat diseases

Answer 4

a

Question 5

describe example: trinucleotide repeat expansion in non-coding region of the FMR1 gene causes Fragile X Syndrome

Answer 5

a

Question 6

Example: trinucleotide repeat expansion in coding region of the HTT gene causes huntingtons disease

Answer 6

a

Question 7

what can spontaneous mutations be caused by

Answer 7

a

Question 8

give ex of spontaneous chemical change to dna - deamination

Answer 8

a

Question 9

give ex of spontaneous chemical change to dna - depurination

Answer 9

h

Question 10

what can lead to permanent dna mutations

Answer 10

a

Question 11

describe molecular basis of induced mutations

Answer 11

a

Question 12

name the 3 mechanisms by which mutagens can induce mutations

Answer 12

a

Question 13

describe some exs of mutagens and their effects - gen

Answer 13

a

Question 14

describe molecular basis of induced mutations - base damage uv light

Answer 14

a

Question 15

describe molecular basis of induced mutations - base damage ionizing radiation

Answer 15

a

Question 16

How do we know if something is a mutagen?

Answer 16

a

Question 17

explain rational behind ames test

Answer 17

a

Question 18

problem with ames test

Answer 18

a

Question 19

Describe ames test for mutagenic compounds - revised

Answer 19

a

Question 20

Why did the revised Ames test include these two different Salmonella strains?

Answer 20

a

Question 21

describe interpretation for ames test for mutagenic compounds

Answer 21

a

Question 22

how can we read and understand a genome

Answer 22

a