Lecture 24 - Pelvic Neuroanatomy Flashcards Preview

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Flashcards in Lecture 24 - Pelvic Neuroanatomy Deck (22):
1

The inferior hypogastric plexus (IHP) is vulnerable to ...

surgical injury

2

Within the IHP there are thousands of...

autonomic neurons - the key to understanding

its not just tracts, its a ganglionated plexus

there is potential to damage cell BODIES

3

INHP damage can damage what..

motor pathway:

postgangionic axons, ganglion cell bodies, preganglionic axons

Sensory pathways: lumbar and sacral sensory axons

4

What does sympathetic nerves do to the bladder?

contraction of bladder base - continence

5

What does parasympathetic nerves do to the bladder?

contraction of bladder dome - micturition

6

What does the sympathetic input do to the reproductive organs in males

ejaculation - contraction of smooth muscle in prostate gland, seminal vesicle, vas, urethea

7

What does the parasympathetic input do to the reproductive organs in males

stimulates prodction of secretions from prostate gland

vasodilation - increased uterine and penile blood flow

8

Sympathetic and parasympathetic axons look __ ___ but can have different _______

Sympathetic and parasympathetic axons look the same but can have different distribution

9

True or false

There is no easily visible synaptic junction

true

10

True or false

there is more than one transmitter release site per axon

true

11

True or false

IHP contains both sympathetic parasympathetic ganglion neurons

true

12

Autonomic neurons in the IHP are sexually dimorphic, meaning...

there are many more neurons in the male.

13

True or false

Receptors for sex steroids do not continue to be expressed in adults

false

they do

steroid levels or drugs that influence steroid actrivity, affect neuron strucutre and fucntion

14

What are some things to consider when investigating ways to undertake safer surgical operations?

the extent of neuron damage - do they die?

understand the innate potential for recovery - can they regrow


Find ways to make damaged axons grow better/faster - clues from developmental neuroscience

Enhance the potential of undamaged axons - indetify compensatory mechanisms, how do we increase the amount of them?

15

What is a way to identify the spinal connectivity of the nerves in the IHP?

microsurgical lesion of the hygogastric nerve will denervate sympathetic neurons - can then identify


can also put in retrograde tracers to trace organ connectivityi

16

With identification of neurons what can then be achieved?

pre-labl then injure selected target-specific neurons - can then compare different types of injury and see the effects:

nerve regrowth
neural activity
drug activation of tissue
contribution of spared nerves

17

the impact of injuring pelvic visceral sensory nerves is likely to be occurring in parallel with..

injuring autonomic nerves

18

What are the potential problems of pelvic sensory nerve damage

loss/reduction of sensroy fucntion to initiate reflexed and tissue receovery from injury/inflammation

initiate state of visceral pain - can be chronic

19

true or false

[retrograde labeling from pelvic organs simultaneously labels autonomic and sensory neurons

true

20

The sensory innervation of pelvic organs originates from ....

dorsal root ganglia of two spinal levels (upper lumbar and sacral)

21

The sensory nerves from pelvic organs are not just sending information about pain, but also

reflex information to do with normal autonomic function

22

visceral sensory neurons branch profused in the SC compared to....

what does this mean for pain?

somatic sensroy neurons

visceral pain more diffuse, poorly localised and often referred

makes sense, the many fibres converge on other sensory fibres.