Lecture 38: Path of Myocarditis, Amyloidosis, Pericardial Disease

Question 1

Coxsackievirus B

Transmission:
Population:
Diagnostic Method:
Dx:

Answer 1

Transmission: fecal oral route, air borne, and surface contact.

Population: children affected most

RT-PCR is diagnostic method of choice

Question 2

Chagas Disease

Causative Agent:

Histopathology:

Answer 2

Caused by parasite T. Cruzii

MCC myocarditis

pseudocysts and mixed inflammatory response of neutrophils, lymphocytes, macrophages, and eosinophils

Question 3

Cardiac Amyloidosis

Answer 3

Tissue stained with Congo red dye exhibiting apple green birefringence under polarized light

Question 4

Pericarditis

Answer 4

Viruses, pyogenic bacteria, TB, fungi and parasites are concurrent with myocarditis.

Secondary causes include RA, SLE, slceroderma, metastatic malignancy

Question 5

Classification of pericarditis

Answer 5

1. purulent or suppurative pericarditis
2. constrictive pericarditis may follow infectious type
3. fibrinous pericarditis is the most common type

Question 6

Cardiac masses

Answer 6

1. cardiac myxoma: in left atrium by echocardiogram

2. Rhabdomyomas are the most common primary cardiac tumor of infants and children.

Question 7

What is gross pathology of cardiac myxoma

Answer 7

friable, gelatinous, red yellow, lobular tumors

Question 8

Rhabdomyomas

Answer 8

Most common primary cardiac tumor of infants ad children

Question 9

Dilated Cardiomyopathy

Answer 9

presents with slowly progressive signs and symptoms of CHF

titin gene

myocarditis, alcohol abuse, pregnancies, drug induced

chamber dilation

Question 10

HCM

Answer 10

genetic autosomal dominant, mutation in beta myosin

leading cause of LVH.

Major abnormality is reduced stroke volume because of impaired diastolic filling

major clinical issues are a. fib, mural thormbi, v arrythmias.

Question 11

Restrictive Cardiomyopathy

Answer 11

characterized by primary decrease in ventricular compliance.

On physical exam rales, peripheral edema, JVD, gallops, tachy

Question 12

Endomyocardial Fibrosis

Answer 12

it is an idiopathic progressive disorder in the tropical regions of the world .

It is considered part of a spectrum of a single disease process that includes eosinophilic endocarditis.

Question 13

Endocardial Fibroelastosis

Answer 13

Very rare and occurs mostly in the first few years of life.

JVD, gallops, tachycardia and regurgitation murmurs