Flashcards in Leukemia Deck (13):
4 types of leukemia?
ALL AML CML CLL
What leukemias happen in midlife?
The M in AML and CML stands for midlife (actually myeloid, but pretend)
Leukemia in children?
Leukemia in elderly?
Kid with bone pain, anemia, frequent infection?
What do you see on smear?
ALL Abundant blasts
PAS and TdT positive
What is Philadelphia chromasone?
15% of adults ALL cases
Drug for it? imatinib
Auer rods? Where do you see those? KNOW THIS!!
Rods in the cells. in AML
What is a smudge cell?
CLL ruptured cell from slide prep b/c lymphocytes are ruptured
What is blast crisis?
Mature myeloid cells to conversion immature blasts
In CML (looks like acute leukemia)
What do you see in CML smear?
Increased myeloid procurers but no smudge!
CML has what chromosome?
PHILE (while CreaM cheese ) 9;22. BCR ABL
tyrosine kinase always on
also rarely in ALL