LG 6.11 - Pharmacokinetics

Question 1

Define a drug’s pharmacokinetic profile?

Answer 1

• ADME
• Absorption
• Distribution
• Metabolism
• Excretion

Question 2

What is the difference between bioavailability and bioequivalence?

Answer 2

• Bioavailability: fraction of drug reaching systemic circulation.
• Bioequivalence: compares drug dosage form made by different manufacturers. Serum concentration time curves from the 2 products must be nearly superimposable, same peak level, time to peak level and AUC.

Question 3

What is the effect by P-glycoprotein?

Answer 3

• A common drug transporter; in GI tract, it can send absorbed drugs back into intestinal lumen, decreasing their absorption and bioavailability.

Question 4

What is the first pass effect?

Answer 4

• Drug is being metabolized by liver before reaching systemic circulation.