Where is AST found?
Liver Heart Skeletal muscle Kidneys Pancreas
Increase in AST/ALT is suggestive of?
Intra-hepatic damage
ALT is found?
ONLY the liver
Marked increase of AST/ALT in the 1000s?
Acute failure due to:
Drugs
Viral hep
Liver ischemia
Modest increase of AST/ALT in the 300-500?
Acute failure due to: Alcohol AI hep Chronic hep Biliary obstruction
Mild increase of AST/ALT below 300?
Cirrhosis NASH Hepatocellular carcinoma Haemochromatosis Wilsons disease
More ALT than AST?
Chronic liver disease
More AST than ALT?
Alcoholic liver disease
Low albumin, low total protein?
Alcoholism Advanced cirrhosis Protein malnutrition Chronic inflammation Nephrotic syndrome
Low albumin, normal protein?
Acute phase reaction - infection
Low albumin, high protein?
Myeloma