LMP301 Lecture 6: Lipids & Cardiac Disease Flashcards Preview

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Ischemic heart disease

Inadequate supply of blood to the heart; some kind of blockage causes heart to stop working.

1

IHD

Ischemic heart disease

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____ of deaths from IHD can be prevented

>1/2

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Differences between men and women in terms of IHD

Symptoms in women are less characteristic than men -> under diagnosis
Risk for men and women are the same

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Disease that may result from fat deposits in the arteries

1. IHD
2. Cerebrovascular disease
3. Peripheral vascular disease

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Cerebrovascular disease

Stroke

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Peripheral vascular disease

Blood can't flow the the extremeties

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Where is the lipid core found?

Nested in the intima

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What holds the lipid core in place?

Fibrous cap

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4 types of lipids

1. Cholesterol
2. Triglycerides
3. Phospholipids
4. FA

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Which lipids are used for fule?

TG and FA

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Which lipids can be found in the membrane?

Cholesterol & phospholipids

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Functions of cholesterol

Production of hormones
Membrane structure

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Functions of phospholipids

Make up cell membranes
Signalling

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Transporter for lipids

Lipoproteins carry circulating lipids in plasma & lympth

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Carriers for FFA

Albumin

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Exogenous pathway for lipids

Lipids consumed from fats

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Endogenous pathway for lipids

Lipids made by the body

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Outline exogenous pathway for lipid metabolism

Dietary fats transported in body by chylomicrons (used in muscle or stored in adipose). Remnant returns to liver to be metabolized. Liver secretes bile which help emulsify fats in the intestines.

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Outine endogenous pathway of lipid metabolism

Liver produces VLDL -> broken down into TG and IDL. TG goes to muscles and adipose tissue while IDL can return to liver or become LDL. LDL deposits cholesterol in extra-hepatic cells, then return to liver.

Liver can also make HDL which picks up extra cholesterol from cells-> return to liver to be metabolized.

Liver produce bile from the cholesterol which is used in the exogenous pathway

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Extra-hepatic cells

Cells other than liver cells

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What does HDL do?

Reverse cholesterol transport

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Reverse cholesterol transport

Take extra cholesterol from cells and returns to liver (prevent buildup)

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List the lipoproteins in order of least dense -> most

1. Chylomicrons
2. VLDL
3. IDL
4. LDL
5. HDL

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Which is the largest lipoprotein?

CM

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Purpose of CM

Transport TG and TC

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What happens to the CM remnant?

Metabolized by the liver to give VLDL

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Purpose of VLDL

Carry mostly TG and some TC to adipose & muscle tissues

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What happens to VLDL during transfer?

Some of it's surface components are lost

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VLDL ->

IDL