M+R Session 10- The ANS Flashcards Preview

SOPHIE'S ESA 2 > M+R Session 10- The ANS > Flashcards

Flashcards in M+R Session 10- The ANS Deck (22):
1

What is the origin of the sympathetic nervous system?

Thoraco-lumbar

2

What is the origin of the parasympathetic nervous system?

Cranio-sacral

3

What is the neurotransmitter present at all preganglionic neurones?

Acetylcholine

4

What is the neurotransmitter present at the postganglionic neurone at each nervous system?

Sympathetic- noradrenaline
Parasympathetic- acetylcholine

5

What is the sympathetic postganglionic neurones neurotransmitter in adrenal glands?

Chromaffin cells

6

What are the receptors that act on the heart? (2)

Beta 1 and M2

7

What are the receptors that are found in vascular smooth muscle?

Alpha 1 and M3

8

What are the receptors found at the lungs?

Beta 2 and M3

9

Which enzyme is required for the production of acetylcholine?

Choline acetyl transferase (CHAT)

10

What is the enzyme required for the breakdown of acetylcholine?

Acetylcholinesterase

11

Why are unwanted side effects a result of muscarinic receptor activation?

Because agents that bind to these receptors are not selective towards them.

12

Which step of noradrenaline synthesis occurs in the vesicles in the preganglionic neurone?

Dopamine-> noradrenaline via dopamine beta hydroxylase enzyme.

13

What do Chromaffin cells release?

Adrenaline, into the bloodstream

14

Where are noradrenaline containing vesicles found in the preganglionic neurone?

Varicosities

15

How is noradrenaline removed from the synaptic cleft?

Via a reuptake system:
-uptake 1- NA is taken up into the pre-synaptic terminal by a sodium dependent transporter.
-uptake 2- any remaining NA is taken up by a lower affinity mechanism.

16

What happens to NA once it has been taken back up into the presynaptic neurone? (2)

-it is repackaged for release again
-it is metabolised by the enzyme Monoamine oxidase

17

What is NA and ACh release regulated by?

Calcium mediated endocytosis

18

Give an example of a nicotinic cholinoceptor antagonist

Tubocurarine

19

Give an example of a muscarinic cholinoceptor agonist and what it treats?

Pilocarpine
Glaucoma

20

Give an example of a muscarinic cholinoceptor antagonist and what it treats?

Ipratropium
Treat bronchoconstriction in asthmatics

21

What does a cholinesterase inhibitor do?

Prolongs the time that ACh is in post ganglionic neurone receptors by preventing acteylcholinesterase from removing ACh.

22

What are the two divisions of the ANS?

Sympathetic and parasympathetic

Decks in SOPHIE'S ESA 2 Class (74):