Flashcards in MOD Session 5- Haemostasis And Thrombosis Deck (21):
The body's response to prevent blood loss and stop bleeding
What is the key step in the coagulation cascade?
What is the main step in the fibrinolytic system?
Plasminogen=> plasmin via plasminogen activators
Plasmin breaks down fibrin.
2 examples of fibrinolytic therapies
Why is streptokinase a fibrinolytic therapy?
It activates plasminogen.
The formation of a solid mass of blood within he circulatory system.
What is Virchow's triad?
States that Thrombosis occurs due to:
- vessel wall abnormalities
- blood flow abnormalities
- blood component abnormalities
Give an example of a blood vessel wall abnormality
Atheroma, direct injury, inflammation
Given an example of a blood flow abnormality
Give an example of why a blood component abnormality arises
Smokers, post-op, pregnancy
The blockage of a blood vessel by a solid, liquid or gas, at a site distant from its site of origin.
What are the 5 types of emboli?
What are the predisposing factors of DVT? (7)
-trauma and severe burns
Why is a massive pulmonary embolism (PE) rapidly fatal?
Causes more than 60% blood flow reduction.
What is given to prevent DVT?
What is the treatment for DVT?
What are the four necessary components for successful haemostasis?
-constriction of blood vessels in the vessel wall
-platelets adhere to each other and the damaged vessel wall to form a plug.
-coagulation system- cascade that converts prothrombin to thrombin, which in turn converts fibrinogen to fibrin.
-fibrinolytic system- activates plasmin through conversion of plasminogen to plasmin, is in turn causes the break down of fibrin.
Give two examples of thrombin inhibitors. What happens if you have a deficiency in them?
Anti thrombin III
Thrombosis of thrombophilia can result.
Describe the appearance of a venous thrombus. (3)
Dark red, soft and has a high cell content
Describe the appearance of an arterial thrombus. (3)
Pale, granular and has a low cell content.