Male phys- montemayor Flashcards Preview

Year2 Repro exam II > Male phys- montemayor > Flashcards

Flashcards in Male phys- montemayor Deck (34)
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1
Q

low total testosterone
high LH and FSH
semen volume and [ ] low
explain high FSH LH

A

because feedback from low testosterone

2
Q

47 XXY

A

klinefelters

3
Q

most common Sx klinefelters

A

infertility and gynecomastia

4
Q

most common genetic form of male hypogonadism

A

klinefelters

5
Q

sex determining region on Y chromosome

A

SRYtranscription factor (testis determining factor

6
Q

what hormone prevents the mullerian ducts from progressing

A

AMH

anti-mullerian hormone

7
Q

what is required for development of seminal vesicles, ejaculatory duct and vas deferens

A

testosterone

8
Q

what cells produce tesosterone

A

leydig cells

9
Q

which hormone stimulates fetal leydig cell production of testosterone during development prior to fetal pituitary LH

A

hCG

10
Q

required for development penis scrotum and prostate

A

DHT

dhydrotestosterone

11
Q

which has highger affinity for Testosterone R

A

DHT

12
Q

what enzyme is required for conversion testosterone- DHT

A

5 alpha reductase 2

13
Q

what produces AMH

A

sertoli cells

14
Q

what promotes development of gynecomastia

A

presence of E
increased E:T ratio
peripheral conversion T to E via CYP 19 aromatase

15
Q

what hormone normally initiates puberty

A

pulsatile GnRH

16
Q

what are gonadotropin levels in primary hypogonadism

A

elevated

androgen decreased

17
Q

major actions of andorgens

A
wolffian structures
erythropoietin synthesis
bone growth
libido
etc..
18
Q

which form is most circulating T found

A

SHBG
serum albumin
least amount is free

19
Q

what protein maintains T [ ] in testes

A

ABP androgen binding protein

20
Q

why is it important for T to be concentrated in testes

A

needs to be at least 100x circulating levels to promote spermatogenesis

21
Q

What promotes secretion of LH and LSH

A

low hormone levels ( E and T)

pulsatile GnRH

22
Q

FSH works on what cells

A

sertoli

23
Q

LH works on what cells

A

leydig

24
Q

Why would continuous GnRH be a Tx for prostate CA

A

constant GnRH dec LH and FSH

so dec T

25
Q

key functions of sertoli cells

A
produce aromatase
maintain blood testis barrier
R for hormones
produce ABP
produce AMH
26
Q

3 key hormones promote adequate spermatogenesis in normal male

A

high T
FSH
LH

27
Q

GH affects spermatogenesis how

A

early division of sperm

28
Q

what Tx could you use for klinefelter Syndrome

A

androgen replacement therapy

29
Q

likely effect of giving exogenous T to klinefelter male

A

virilization of secondary male sexual traits

30
Q

can exogenous T of klinefelters male promote fertility?

A

no

seminiferous tubule likely is destroyed

31
Q

failure of testes to descend impairs what aspect of repro function

A

maturation of spermatogonia because of temperature differene

32
Q

dec in facial and axillary hair and dec penile length and hypogonadism
deficiency in what androgen explains findings

A

DHT

33
Q

generate Ab that bind and neutralize FSH bioactivity

expected to have a feedback decrease in what

A

decreased serum inhibin B levels

34
Q

sertoli cells normally do what in seminiferous tubules

A

maintain blood testis barrier