Male phys- montemayor Flashcards Preview

Year2 Repro exam II > Male phys- montemayor > Flashcards

Flashcards in Male phys- montemayor Deck (34):
1

low total testosterone
high LH and FSH
semen volume and [ ] low
explain high FSH LH

because feedback from low testosterone

2

47 XXY

klinefelters

3

most common Sx klinefelters

infertility and gynecomastia

4

most common genetic form of male hypogonadism

klinefelters

5

sex determining region on Y chromosome

SRYtranscription factor (testis determining factor

6

what hormone prevents the mullerian ducts from progressing

AMH
anti-mullerian hormone

7

what is required for development of seminal vesicles, ejaculatory duct and vas deferens

testosterone

8

what cells produce tesosterone

leydig cells

9

which hormone stimulates fetal leydig cell production of testosterone during development prior to fetal pituitary LH

hCG

10

required for development penis scrotum and prostate

DHT
dhydrotestosterone

11

which has highger affinity for Testosterone R

DHT

12

what enzyme is required for conversion testosterone- DHT

5 alpha reductase 2

13

what produces AMH

sertoli cells

14

what promotes development of gynecomastia

presence of E
increased E:T ratio
peripheral conversion T to E via CYP 19 aromatase

15

what hormone normally initiates puberty

pulsatile GnRH

16

what are gonadotropin levels in primary hypogonadism

elevated
androgen decreased

17

major actions of andorgens

wolffian structures
erythropoietin synthesis
bone growth
libido
etc..

18

which form is most circulating T found

SHBG
serum albumin
least amount is free

19

what protein maintains T [ ] in testes

ABP androgen binding protein

20

why is it important for T to be concentrated in testes

needs to be at least 100x circulating levels to promote spermatogenesis

21

What promotes secretion of LH and LSH

low hormone levels ( E and T)
pulsatile GnRH

22

FSH works on what cells

sertoli

23

LH works on what cells

leydig

24

Why would continuous GnRH be a Tx for prostate CA

constant GnRH dec LH and FSH
so dec T

25

key functions of sertoli cells

produce aromatase
maintain blood testis barrier
R for hormones
produce ABP
produce AMH

26

3 key hormones promote adequate spermatogenesis in normal male

high T
FSH
LH

27

GH affects spermatogenesis how

early division of sperm

28

what Tx could you use for klinefelter Syndrome

androgen replacement therapy

29

likely effect of giving exogenous T to klinefelter male

virilization of secondary male sexual traits

30

can exogenous T of klinefelters male promote fertility?

no
seminiferous tubule likely is destroyed

31

failure of testes to descend impairs what aspect of repro function

maturation of spermatogonia because of temperature differene

32

dec in facial and axillary hair and dec penile length and hypogonadism
deficiency in what androgen explains findings

DHT

33

generate Ab that bind and neutralize FSH bioactivity
expected to have a feedback decrease in what

decreased serum inhibin B levels

34

sertoli cells normally do what in seminiferous tubules

maintain blood testis barrier