UTI STI drugs Kinder Flashcards Preview

Year2 Repro exam II > UTI STI drugs Kinder > Flashcards

Flashcards in UTI STI drugs Kinder Deck (29)
Loading flashcards...
1

what drug class is amoxicillin

beta lactam

2

amoxicillin is drug choice for what bacteria

enterococci

3

drugs of choice for Tx of uncomplicated cystitis

TMP.SMX
nitrofurantoin
fosfomycin

4

MOA TMP SMX

inhibits folic acid synthesis in bacteria
SMX- dihydropteroate synthestase
TMP- dihydrofolate reductase

5

MOA nitrofurantoin

drug reduced, damage DNA

6

MOA fosfomycin

inhibits early stage cell wall synthesis
decreased formation N acetylmuramic acid

7

drug of choice for klebsiella

TMP SMX

8

most common microbe in uncomplicated bladder infections

1- e coli
2- saprophyticus

9

Tx for saprophyticus

1st generation cephalosporin or TMP SMX

10

Tx e coli cystitis

TMP sMX

11

Tx proteus mirabilis cystitis

TMP SMS

12

Tx enterococcus cystitis

ampicillin amoxicillin

13

rule out what in cystitis

pyelonephritis

14

when do you decide not to use TMP SMX for e coli infection

if >20% Resistant

15

what to use if E coli R cystitis

ciprofloxacin

16

what antibiotics can increase warfarin INR

TMP SMX-- inhibits CYP2C9

17

what antibiotics can enhance anticoagulant effect warfarin

amoxicillin
azithromycin

18

Vit K dependent coagulation factors

2 7 9 10 and protein C and S

19

how does warfarin work

depletes vit K stores so depletes the vit K dependent factors

20

which warfarin is more potent

S warfarin- CYP2C9

21

recurrent UTI definition

>2 in 6 mo or >3 in 1 year

22

risk factors for multidrug R organisms

hospitalization in last 6 mo
urinary catheter
nursing home resident

23

what organisms do you worry about for multidrug R urine bacteria

pseudomonas and enterococci

24

in patient Tx pyelonephritis

IV
fluroquinolones
aminoglycoside +/- ampicillin
extended spectrum cephalosprin or sextended spectrum penicillin +/- aminoglycoside
carbapenem--- multidrug R

25

how does ciprofloxacin work

targets DNA gyrase and topoisomerase IV

26

what drug can interact with cipro

divalent/trivalent cations impair absorption
e.g. Ca carbonate

27

macrolides work where

50 s ribosomes inhibiting protein synthesis

28

MOA aminoglycosides and tetracyclines

30 s

29

main adverse drug reaction azithromycin

nausea