Martin, drugs for male GU Flashcards Preview

Year2 Repro exam II > Martin, drugs for male GU > Flashcards

Flashcards in Martin, drugs for male GU Deck (44)
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1

What drugs are used for BPH

5a-reductase inhibitors
alpha adrenergic antagonists
saw palmetto

2

what drugs are used for ED

PDE 5 inhibitors
alprostadil

3

what are the 5alpha reductase inhibitors

finasteride and durasteride

4

what are the alpha adrenergic antagonists

prozosin
terzosin
doxazosin
alfuzosin
tamsulosin
silodosin

5

what are the PDE 5 inhibitors

sildenafil(viagra)
tadalafil
vardenafil
avanafil

6

MOA 5 alpha reductase inhibitor

inhibition 5a reductase reduces levels of dihydrotestosterone within 8 hours

7

adverse effects 5 alpha reductase inhibitors

impotence and decreased libido

8

which 5 alpha reductase inhibitor preferentially antagonizes type II 5 alpha reductase

finasteride

9

finasteride also approved to Tx what

male pattern baldness
hirsutism in women

10

what drug has a longer half life than finasteride

dutasteride

11

clinical manifestations of BPH

increased frequency of urination, nocturia, hesitancy, urgency and weak urinary system

12

when does tx start for BPH

Sx have significant impact on patients life

13

alpha adrenergic antagonists are used to Tx what

pheochromocytoma, primary HTN, BPH, Ischemic HD, arrhythmias, endocrinologic and neurologic disorders and glaucoma

14

most common cause ED

atherosclerosis

15

what R mediate smooth muscle tone in prostate

alpha 1

16

what are the long acting alpha adrenergic antagonists

everyone EXCEPT prazosin

17

which alpha antagonist has more CV side effects

prazosin

18

adverse effects prazosin

palpitations and orthostatic hypotension/syncope

19

common drugs that alter sexual response

SSRIs antidepressants
spironolactone and thiazide diuretics
antipsychotics-phenothiazines
benzodiazepines, alcohol, cocaine, marijuana, hallucinogens
nonselective beta blockers
centrally-acting sympatholytics

20

which alpha antagonist is selcetive for a1A and a1D

tamsulosin

21

adverse effect tamsulosin

abnormal ejaculation

22

MOA saw palmeto

inhibits 5 alpha reductase I and II and inhibits dihydrotestosterone binding to androgen R

23

saw palmetto is better for what stage BPH

mild to moderate

24

MOA PDE 5 inhibitors

selective inhibition of PDE-5 increase intracavernosal cGMP levels and causes relaxation of the nonvascular smooth muscle of corpora cavernosa

25

which PDE5 inhibitor has effects that can last 36 hrs

tadalafil

26

drug interactions with PDE5 inhibitors

use with nitrates can lead to severe hypotension and syncope

27

adverse effects PDE 5 inhibitors

visual changes and hearing loss

28

will PDE5 inhibitors work in men with loss of potency due to a cord injury

no

29

why does an erection require relaxation of nonvascular smooth muscle

permits inflow of blood which P causes the erection

30

what is alprostadil

PG E1 analog that relaxes trabecular smooth muscle by dilating cavernosal aa