male reproductive endocrinology W8

Question 1

requirements for normal male reproductive development and function?

Answer 1

gonadal and reproductive system development
intact reproductive hormone production
puberty
spermatogenesis
normal spermatozoa
erectile function
non-obstructive anatomy

Question 2

sex determination and differentiation - male pathway?

Answer 2

genetic sex -> testis formation -> testosterone

Question 3

HPG axis - fetal? (male)

Answer 3

HPG axis active in fetal life
testosterone produced important for development of male reproductive system
this lasts until birth

Question 4

anti-mullerian hormone?

Answer 4

produced by sertoli cells in testis
induces regression of mullerian ducts (oviducts, uterus, vagina)

Question 5

when is the HPG axis active in infancy?

Answer 5

soon after birth, lasts until 3 months postnatally
purpose unknown
gives us a window for investigating reproductive function

Question 6

HPG axis in childhood?

Answer 6

inactive
no testosterone or sperm
prepubertal testis do have germ stem cells, sertoli cells and leydig cells

Question 7

HPG axis in puberty?

Answer 7

ages 9-14
responsible for initiation of spermatogenesis and secondary sexual characteristics

Question 8

HPG axis function in adulthood?

Answer 8

brain - libido, aggression
skin - hair growth, balding, sebum production
muscle - increase in strength and volume
liver - synthesis of serum proteins
male sexual organs - penile growth, spermatogenesis, prostate growth and function
bone marrow - stimulation of sperm cells
bone - accelerated linear growth, closure of epiphyses