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Flashcards in mediators of inflammation Deck (40):
1

three stages of inflammatio

acute, subacute, chronic

2

what orchesrates inflammatory response?

mediators

3

pleiotropic

could have more than one response

4

cell derived mediatorys

vasoactive amines
enzymes
prostgladins
cytokines + chemokines
neuropeptides

5

plasma derived mediators

complement system
kinin system
coagulation (clotting) system

6

once mediatory released from the cell

short lived, decay quickly and inactivated or inhibited

7

vasoactive amines

(preformed mediators)

histamine- vasolidation, vascular permeabilty
(mast cells, basophils, platelts)

serotonin - vasoconctrstion
(platlets)

8

Leukocyte Lysosomal Enzymes
(prefroemd mediators)

secreted (elastase)- destroy and digest microbes
*destroyed phagocytosed substances
* casues tissue damage

(ex. elastase, collagenase, cathepsin)

9

newly synthesized mediators
AA

eicosanoids

20-carbn
cell membrane phospholipid coponets
(mast cells, leukocytes endothelial cells)

10

AA mechanism

power point

11

Newly Synthesized : PAF

phospholipid-derived mediator--
* aggregates platlets
vasodialtion
increased permeabilty
chemotaxis

12

PAF mechanism

POwerpoint

13

cytokines

polypeptide products of many cell types

14

abudnatly produced by what?

macrohphage and lymphcoytes

15

action and effects of chemokines

autocrine
paracrine
endocrine

16

major cytokines in acute inflammation

TNF, Il-1, Il-6, chemokines

17

cytokines principle role is?

endothelial activation

18

chronic inflamation cytokines

Il-12 and IFN-y

19

chemikines

chemoattractants for leukocytes

20

function of chemokines

leukocyte recruitment
control cellular organization
activate leukocytes

21

classification
cxc chemokines

Il-8 ==> acute

22

classification cc chemokines

Mcp, mip rantes==>chronic

23

chemokines regulate?

cell trafficking

24

cells migrate toward during chemotaxis to?

toward higher concentraion of chemokines

25

neuropeptides

play a role in
pain, regulate vessel tone
vascular permeabilty

26

Calcitonin Gene Related Peptide

vasodialtion
transmit pain signals

27

what releases ROS

activated pmns and macrophages

28

lysosomal ros

destroy phagocytosied microbes and necrotic cellls

29

secreted ros low levels

^ chemokine, cytokine, adhesion molecule

30

secretied ros high levels

endotheial damage, ^ permeabilty
direct cell injury

31

NO endothieal

eNOS (anti-inflammatory effects)
* vasoliation
*reduced adhesion

32

NO macrophage

iNOS
* cytotoxic

33

plasma protein derived mediators
Hageman Factor

complement
kinin
coagulation

34

how is inflammation turned off

short lived
endogenous
anti inflammator
pharmaceuticals

35

anti-inflammatory cytokines

iL-10-inhibts TNF
IL-2, IL-4 - promote repair

36

endogenous "anti" mediators

antioxidants, lipoxins, protease inhibits, resolvins

37

pharmaceuticals

nsaids (blocks cyclooxygenase (PG production

steroids - block PLA2 (aa formation)

Etanecceot - block action of TNF

antihistamines

38

plaque biofilm reases

toxins, cytokines (LPs, TNF, IL1,8, PGE2)

39

Periodontics

ongoing inflamamtion/infection (CRP, fibrinogen, Il-6)

40

Sysremic disease with oral health disease

cardiovascular disease
diabetes
COPD