mediators of inflammation Flashcards
three stages of inflammatio
acute, subacute, chronic
what orchesrates inflammatory response?
mediators
pleiotropic
could have more than one response
cell derived mediatorys
vasoactive amines enzymes prostgladins cytokines + chemokines neuropeptides
plasma derived mediators
complement system
kinin system
coagulation (clotting) system
once mediatory released from the cell
short lived, decay quickly and inactivated or inhibited
vasoactive amines
preformed mediators
histamine- vasolidation, vascular permeabilty
(mast cells, basophils, platelts)
serotonin - vasoconctrstion
(platlets)
Leukocyte Lysosomal Enzymes
prefroemd mediators
secreted (elastase)- destroy and digest microbes
- destroyed phagocytosed substances
- casues tissue damage
(ex. elastase, collagenase, cathepsin)
newly synthesized mediators
AA
eicosanoids
20-carbn
cell membrane phospholipid coponets
mast cells, leukocytes endothelial cells
AA mechanism
power point
Newly Synthesized : PAF
phospholipid-derived mediator-- * aggregates platlets vasodialtion increased permeabilty chemotaxis
PAF mechanism
POwerpoint
cytokines
polypeptide products of many cell types
abudnatly produced by what?
macrohphage and lymphcoytes
action and effects of chemokines
autocrine
paracrine
endocrine
major cytokines in acute inflammation
TNF, Il-1, Il-6, chemokines
cytokines principle role is?
endothelial activation
chronic inflamation cytokines
Il-12 and IFN-y
chemikines
chemoattractants for leukocytes
function of chemokines
leukocyte recruitment
control cellular organization
activate leukocytes
classification
cxc chemokines
Il-8 ==> acute
classification cc chemokines
Mcp, mip rantes==>chronic
chemokines regulate?
cell trafficking
cells migrate toward during chemotaxis to?
toward higher concentraion of chemokines
