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Flashcards in Principles of inflammation 1 Deck (33):
1

causes of inflammation
physical:

trauma, surgery

2

causes of inflammation
chemical:

mediical drugs

3

causes of inflammation
infection

bacteria, fungi, virsus

4

causes of inflammaion
immune reaction

allergy, auto-immune

5

inflammation signs

red, warm, swelling, pain --or loss of function

6

inflamamtion events (1-3)

vasoconstriction, vasodialation, statis-capillaries + venules

7

vasodialation

increased blood flow
leads to erthema and heat

8

statis-caillaries and venules

hemonconcentration -> ^ viscosisty
margination of leukocytes

9

Permeability mechanisms
endothelial gaps

rapid/short lived
reversible
due to endothelial contraction
mediated by histamine

10

permeability mechanism
direct injruy

arterioles, capillaries
toxins, burn, chemicals
rapid/long lived

11

Permeabilty mechanism
leukocyte-dependent injury

ppolys cause injury when adhere to endothelim
-->release of free radicals

12

Permeability mechanism
Transcytosis

early response
transport endothelim via cytoplasmic vesicles
mediated by VEGF--> new vessels forming

13

Results in early acute inflammtion

edema (Extracellular h2o)
hemoconcentration (intravascular) from fluid loss
pain from press within tissues

14

transudate

fluid clear and mostly water

15

exudate

fluid, protein, cells

16

inflammation events 4-9

margination
rolling *
adhesion *
transmigration *
chemotaxis
phagocytosis

17

what is margination based on

slow flow, not adhesion

18

molecules : rolling --> adhesion

selections

19

molecules: adhesion -->transmigration

integrins

20

selectins

transmembrane proteins
lectin domain binds to carbs
* binds to addressins with Lewis X
*weak

21

intergrins (30 protein family)

bind to endothelium

22

immunoglobin superfamily

bind to intergrins on WBCs

23

importance of P-Selection

binds to Lewis X (all wbcs)
primes cells for rolling

24

improtance of ELAM-1 (E-selections)

binds to Lew X (poly, mono)
invlved in rolling

25

importance of ICAM -1

binds to an integrin CD18 (all wbcs)
involed in adhesion

26

why dont endothelium and wbcs sick together all the time?

weibel-palade bodies

27

what is used by all wbcs to migrate between endo cells

PeCAM (homotypic) -->pierces membrane using collagenases

28

transmigration

wbcs move through vessel wall
poly after 24
mon after 48

29

chemotaxis

wbcs attracted to injury
mediators like c5a, LTB4, IL-8

30

chemotaxis mechanism

c5a binds-->activates phos lipase -->PIP2 -->IP3--->increased Ca++-->Assembly of contracile proteins-->cell motility

31

what regulates cell traficking?

chemotactic factors

32

where do cell move toward during chemotaxis

toward high concenration of chemokines

33

phagocytosis

pmns-sloppy eats
macro-polite eater