Principles of Inflammation 2 Flashcards Preview

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Flashcards in Principles of Inflammation 2 Deck (50):
1

what can apmplify a reaction?

mediators

2

what induces cell necrosis?

C5 - 9 MAC (membrane attack complex)

3

what effects are > than C3a

C5a, chemotactic for polys

4

Hageman factor

triggers kinin system cascade

5

plasmin

activates hageman factor, cleaves c3 + c5

6

what increases vascular permeability

when fibrin split products

7

fibrin is formed -->

vascular occlusion which may lead to ischemia

8

IL-6 fever

^ CRP production by liver

9

Endothelial damage

during wbc adhesion to endothelium

10

anti-oxidants

superoxide dismutase
catalase

11

sources of free radical

radition
phagocytosis, inflammation
mitochondria

12

free radicals especially bind to

thymine --> DNA breaks

13

free radicals on protein cross-linking

leads to enhanced degradation

14

managment system to deal with free raidcals

SOD converts
O2 ->H2O2 + O2

15

what can purines bind to?

receptors of platelets for activation and aggregation

16

what can be released from polys?

purines ATP and ADP

17

what reverses inflammtion? (5)

chalones
hemostasis
reducing swelling (lymphatics drain edema fluid from site)
mediators
anti-oxidants

18

eNO reduces?

rollng + adhesion

19

Lipoxins (reverse of inflammation)

part of lipo-oxygenase pathway

20

what stops IL-1 production

pyrin (marenostrin)

21

what triggers formation of inflammasome

bacterial endotoxins, cell necrosis and cytkines

22

what activates IL-1

caspase 1

23

what blocks activation of caspase1

pyrin

24

antiinflammatory drugs

antihistamins
corticosteroids
nsaids
leukotreine drugs

25

vasoactive amines (histamine)

released from mast cells
induced by injury
reorient WP bodies (p-selection

26

lysomal constiuents (enz)

released from polys, macrophage
tissue destruction and permeabiltiy

27

IL-8

chemotaxis for polys

28

acute-short duration of inflammation

polys predominate

29

subacute-intermiedaite duration of inflammation

polys, granulation tissue + round cells

30

chornic-long duration of inflammation

no polys, -->healing with collagen
lympcotes, macrophages and plasma cells

31

chronic-granuomatous
features:

localized, replaces normal tissue
giant cells, necrosis

32

chronic-granulomatous
general causes:

delated hypersensivity, foriegn material

33

chronic-granulomatous
specific causes:

TB, fungus, syphilis, sutures

34

what is a ganuloma

macrophages fused together forming giant cells

35

what influences grnaulomas

IL-4 made by Th2 cells

36

what does granuloma cause?

E-caderin expression on cell surface and fusion

37

serous

watery blister

38

effusion

serous fluid in body cavity

39

catarrhal

water + mucous

40

fibrinous

fibrin on surfaces

41

purulent

pus with polys abcess

42

hemorrhagic

vascular damage-bacteria

43

pseudomembranous

dead cells + polys

44

increased pmns in blood

leukocytosis

45

Esoinophilic leukocytosis

allergic reactions, parasiic infections

46

acute phase reactants include

fibrinogen, glibulins, C-reactive protein and protein SAA

47

Elevated CRP

post op, after acute MI, infections, inflammatory disease

48

CRP rises in serum after

4-6 hours

49

stimulant of increased hapatic CRP production

IL-6

50

ESR elevated in patients with inflammation

system inflammatory disease, infection