Menopause Flashcards Preview

Jason's MD3 Women's > Menopause > Flashcards

Flashcards in Menopause Deck (30):
1

Blood test for menopause?

Unreliable
FSH usually gradual rise

2

Menopause hormones?

Decreased estradiol/progesterone
Androgen same

3

Premature menopause is when?

4

Smoking and menopause?

1-2 years earlier if smoker

5

Hysterectomy for menopause?

Reduced age of menopause

6

Menopause cause?

Run out of oocytes

7

Accelerated loss of ovarian primordial follicles at what age?

37

8

Risk of irregular anovulatory cycles?

Prolonged unopposed estrogen
Endometrial hyperplasia and cancer
NEEDS investigations

9

Consequences of menopause? Short term?

Vasomotor symptoms (hot flushes)
Vaginal dryness, atrophic vaginitis
Sleep disturbance
Mood disturbance

10

Medium to long term consequences of menopause? More likely if early menopause

Bone density
Risk of #s
Alzheimer's
Cardiovascular

11

Ask what for menopause?

What is impacting them the most? Directs management

12

What happens if you have irregular periods in the perimenopausal time?

Need to investigate, could be endometrial cancer, pregnant,

13

When do hot flushes end?

50% Most women: will last 5-8 years

14

What are skeletal toxin?

Excess alcohol and caffeine

15

Iatrogenic causes of premature menopause?

Chemo or radiation for cancers

16

When is early menopause?

40-45

17

When is premature menopause?

Before 40

18

Other reasons for premature menopause? Genetic?

Turner's, fragile X
Autoimmune

19

Dx of premature menopause?

Amenorrhoea greater than 4 months

20

Dx of premature menopause?

FSH, E2 on two occasions
Prolactin, TFT bHCG
Karyotyping

21

What is in HRT?

Estrogen to treat symptoms
Progesterone to protect endometrium

22

Best way to give HRT?

Transdermal, less likely to get DVTs

23

What to do with premature menopause HRT?

Take COC

24

HRT used for how long?

Shortest time, lowest dose to take care of symptoms

25

Oestrogen alone bad how?

Risk of trike
VTE, PE
Cholecystitis
Endometrial hyperplasia and cancer for woman with uterus

26

Combined HRT risks?

Breast cancer IF >5 years

27

Contraindications for HRT

Hormone sensitive cancers

28

Tibolone is?

Weak estrogen

29

What do no hormonal therapies change?

Only vasomotor symptoms
NOT depression, sleep, urogenital.

30

What available non-hormonal therapies?

Gabapentin
SSRI/SNRI
Clonidine