Red Cell Iso-Immunization Flashcards Preview

Jason's MD3 Women's > Red Cell Iso-Immunization > Flashcards

Flashcards in Red Cell Iso-Immunization Deck (23):
1

2 kinds of antibodies

Auto-antibodies + fetus
Allo-antibodies, no damage to mother, damage fetus

2

Common maternal autoimmune

-Thyroid auto-immune: grave's
-Connective tissue diseases - SLE,
Schrogen's: Auto Rho, LA
-Fetus: heart block/cardiomyopathy
-Immune Thrombocytopenia Pupura

3

3 iso-antibodies

Red Cell Isoimmunisation
Perinatal allo-immune thrombocytopaenia
Perinatal neutropenia

4

If no platelets, where does fetus bleed from?

GI
Intracranial

5

Neutropaenia

Overwhelming bacterial infection.
In birth: ecoli, GBS, GAS

6

What to give baby with no white cells?

Abx
IgG

7

Why don't give baby with no white cells.... White cells?

Graft vs. Host

8

Harmful Red cell antigens

Rhesus c/C, d/D, E/e
Kell, Kidd, Duffy
MNS

9

What most important red cell antigen?

D +/-c,E (85%)


Kell, c,E,Fya

10

What happens in severe neonatal jaundice? From red cell haemolysis?

Kernicterus: permanent brain damage
Hydrops: cardiac failure
FDIU

11

Primary immunisation? 3

1. Blood transfusion
2. Feto-Maternal haemorrhage

12

When does is feto-maternal haemorrhage happen?

Abortion, miscarriage, ectopics, Antepartum haemorrhage

CVS, Amnio, Version, MVA
Spontaneous

13

How to protect against occult feto maternal haemorrhage?

Prophylactic Anti-D at 28&24 weeks (90%)

14

anti-body titre threshold?

>512

15

Low risk ab titre?

16

Moderate ab titre?

64-256

17

Medium risk antenatal care?

U/s Screen at 20 weeks
-MCA peak systolic velocity
CTG at 32 weeks
Deliver at 38

18

Intrauterine transfusion, if need to give mother blood, can you do it?

Yes, only the red cells, no plasma, but in practice would use donor blood.

19

Most sensitive thing for hypovolaemia in young person?

Postural hypotension

20

Store what blood in hospitals for any woman of child-bearing age?

Kell -ve
D -ve blood

21

Contraindication to passive-antiD?

If already imunised

22

Timing of Anti-D passive administration?

Within 72 hours

23

Anti-D what kind of ab?

IgG
Won't harm baby because titre is too low