Flashcards in First Trimester Screening Deck (22):
What to predict with first trimester screening?
Prevalence in chromosomal abnormalities in order?
T21, T18, T13, Turners, sex trisomies
Maternal age a good population screen?
Not really, only detected 20% of T21 with amniocentesis
What is quadruple test in T2?detection rate?
Detection is 75% for T21
Nuchal translucency threshold? Also detection rate?
Above 95centile, above 3mm
When can you measure Nuchal translucency?
11-13 weeks, when Crown rump length is between 45-84
T21 first trimester bio markers?
Free BHCG - High
PAPP-A - Low
T18 and T13 bio markers levels used with Nuchal translucency
Free BHCG - low
Detection rate of bio markers + Nuchal translucency?
Adding nasal bone or tricuspid Regurg or ductus venosum to the bio markers plus Nuchal translucency?
CVS, why sensitivity not 100%?
Problems with microarray in 2016?
2% of population might have Variations of unknown significance detected. Can microarray parents to get an idea
Risk of amniocentesis/CVS for miscarriage for %?
0.2% - CVS
Fetal cell free DNA % in maternal circulation?
10% in maternal circulation
Meta-analysis of NIPT what is detection rate for trisomies?
T21: 99%, 0.08 false positive
Problems with microdeletions In microarray?
Because they're so rare, you'll get more false positives
NIPT probs for T21?
low fetal fraction in high BMI
Maternal age not factored in
NIPT for sex chromosomes?
Not very good
Nuchal translucency less than how many mm is good chance of normal preg?
Less than 3.4mm. 95% chance of normal
Screening markers for early onset preeclampsia?
Hx+ Mean arterial BP + ultrasound uterine artery Doppler + PAPPA and Placental growth factor
Preeclampsia detection, how to prevent?