First Trimester Screening Flashcards Preview

Jason's MD3 Women's > First Trimester Screening > Flashcards

Flashcards in First Trimester Screening Deck (22):
1

What to predict with first trimester screening?

Trisomies
Preeclampsia
Fetal growth
Preterm
GDM

2

Prevalence in chromosomal abnormalities in order?

T21, T18, T13, Turners, sex trisomies

3

Maternal age a good population screen?

Not really, only detected 20% of T21 with amniocentesis

4

What is quadruple test in T2?detection rate?

HCG
AFP
Unconjugated estriol
Inhibit-A
Detection is 75% for T21

5

Nuchal translucency threshold? Also detection rate?

Above 95centile, above 3mm
Detection: 80%

6

When can you measure Nuchal translucency?

11-13 weeks, when Crown rump length is between 45-84

7

T21 first trimester bio markers?

Free BHCG - High
PAPP-A - Low

8

T18 and T13 bio markers levels used with Nuchal translucency

Free BHCG - low
PAPP-A -Low

9

Detection rate of bio markers + Nuchal translucency?

90%

10

Adding nasal bone or tricuspid Regurg or ductus venosum to the bio markers plus Nuchal translucency?

96%

11

CVS, why sensitivity not 100%?

Placental mosaicism

12

Problems with microarray in 2016?

2% of population might have Variations of unknown significance detected. Can microarray parents to get an idea

13

Risk of amniocentesis/CVS for miscarriage for %?

0.1% -amnio
0.2% - CVS

14

Fetal cell free DNA % in maternal circulation?

10% in maternal circulation

15

Meta-analysis of NIPT what is detection rate for trisomies?

T21: 99%, 0.08 false positive
T18: 96.8%
T13: 92.1

16

Problems with microdeletions In microarray?

Because they're so rare, you'll get more false positives

17

NIPT probs for T21?

low fetal fraction in high BMI
Maternal age not factored in

18

NIPT for sex chromosomes?

Not very good

19

Nuchal translucency less than how many mm is good chance of normal preg?

Less than 3.4mm. 95% chance of normal

20

Screening markers for early onset preeclampsia?

Hx+ Mean arterial BP + ultrasound uterine artery Doppler + PAPPA and Placental growth factor

21

Preeclampsia detection, how to prevent?

Low-dose aspirin

22

How does aspirin improve things in preg?

Improve trophoblast function, improve cytokines profile, and PLGF