Metabolism V - Week 1

Question 1

What happens to amino acids which are not used?

Answer 1

Degraded

Question 2

Where are amino acids degraded?

Answer 2

Liver

Question 3

Amino acids mainly come from…

Answer 3

Absorption from our food

Question 4

Proteins are broken into amino acids using…

Answer 4

Proteolytic enzymes

Question 5

What is contained in the amino group?

Answer 5

NH3

Question 6

Amino acid initially produces…

Answer 6

NH3 & NH4+

Question 7

Which waste product must be excreted in amino acid degradation?

Answer 7

NH4+

Question 8

What is the major excretion molecule for nitrogen?

Answer 8

Urea

Question 9

Where is urea produced?

Answer 9

Liver

Question 10

What is the first step in synthesis of urea?

Answer 10

Amino acid converted to keto acid in transamination

Question 11

What is the second step in the synthesis of urea?

Answer 11

Amino group removed producing NH4+ - deamination

Question 12

What is the third step in the synthesis of urea?

Answer 12

Urea cycle- NH4+ combined with aspartic acid to make urea

Question 13

Which enzymes are used in transamination?

Answer 13

Aminotransferases

Question 14

Which waste product is usually made in transamination?

Answer 14

Glutamate

Question 15

What is made after amino groups are recomved?

Answer 15

Carbon skeletons

Question 16

What is the fate of carbon skeletons?

Answer 16

Oxidised to glucose or in the TCA cycle or be converted to ketone bodies`

Question 17

Give 3 examples of amino degradation disorders.

Answer 17

Alcaptonuria, maple syrup urine disease, Phenylketonuria

Question 18

Urea cycle disorders result in…

Answer 18

Accumulation of urea cycle intermediates and hence NH4+