Methylprednisolone G2

Question 1

Methylprednisolone Class

Answer 1

• Corticosteroid (synthetic glucocorticoid)
• Anti-inflammatory

Question 2

Methylprednisolone MOA

Answer 2

• Suppresses acute and chronic inflammation
• Potentiates smooth muscle relaxation by beta adrenergic agonists

Question 3

Methylprednisolone Indications

Answer 3

• Allergic reactions, anaphylaxis, asthma/reactive airway disease/bronchitis
• Adrenal insufficiency or long-term steroid dependence induced shock
• Burns potentially involving the airways.

Question 4

Methylprednisolone Adult dose

Answer 4

• 2 mg/kg IV/IO slowly or IM (max dose 125 mg)

Question 5

Methylprednisolone Contraindications

Answer 5

• Known hypersensitivity
• Severe untreated infections
• Pre-term infants

Question 6

Methylprednisolone Adverse reactions

Answer 6

• Nausea & vomiting if given to fast

Question 7

Methylprednisolone Pediatric dose

Answer 7

• Status asthmaticus, anaphylaxis, shock with history of adrenal insufficiency:
  • Loading dose: 2 mg/kg IV/IO slowly or IM (max single dose 60 mg)
  • Maintenance dose: 0.5mg/kg every 6 hours or 1 mg/kg every 12 hours (max total dose 120 mg in 24 hours)