Morphine G1

Question 1

Morphine Class

Answer 1

• Opioid analgesic (Schedule II drug)

Question 2

Morphine MOA

Answer 2

• Elevates pain threshold by acting on the pain receptors in the CNS.
• Depresses respiratory and fear/anxiety centers in the brain.
• Increased vasodilation reduces preload and afterload, decreasing myocardial oxygen demand.

Question 3

Morphine Indications

Answer 3

• Management of acute pain

Question 4

Morphine Adult dose

Answer 4

• Pain management:
• 2 – 4 mg slow IV/IO push; may repeat with 2 – 8 mg in 5 – 15 min. as needed
• 0.1 mg/kg IM (max dose of 5 mg)
• Acute chest pain with ST-elevation:
• 1 – 5 mg slow IV/IO push; may repeat as needed

Question 5

Morphine Contraindications

Answer 5

• Known hypersensitivity
• Hypoventilation or hypoxia despite high-flow oxygen
• Head injuries, seizures, or brain tumors
• Acute or severe asthma (relative)
• Delirium tremens
• Cor pulmonale

Question 6

Morphine Adverse reactions

Answer 6

• CV: bradycardia, tachydysrhythmias, orthostatic hypotension
• Resp: respiratory depression or apnea
• CNS: confusion, headache, seizures, syncope
• GI: nausea and vomiting

Question 7

Morphine Pediatric dose

Answer 7

• 0.1 – 0.2 mg/kg slow IV/IO/IM push (max dose of 5 mg)