Micro-Para-Virology Flashcards
(32 cards)
Factor causing Necrosis in C. perfringens
£ Factor
Factor causing ‘whooping’ cough in Pertussis (Tuspirina)
Pretracheal cytotoxin
-damages ciliated cells
Current bird flu
H7N9
Factor for Hemoglobin breakdown in P.aeruginosa
Verdoglobin
- pyocyanin - pigment damages colia & mucosal cells
- exotoxin A - tsx necrosis; inactivates EF-2; TYPE III SECRETION SYSTEM - facilitates exotoxin transfer
Pontiac fever Shanghai fever Staccato cough Bird Fancier's dsx Valley fever Damson Disease Expatriate Syndrome Tropical Pulmonary Eosinophilia River blindness
Pontiac fever - Legionella (Silver stain)
Shanghai fever - Pseudomonas (Cetrimide agar)
Staccato cough - Chlamydia D-K (neonatal)
Bird Fancier’s dsx - C psittaci
Valley fever - Coccidioses
Damson Disease - SSPE
Expatriate Syndrome, Tropical Pulmonary Eosinophilia (Nocturnal wheezing) - Filariasis
River blindness - Drancunculus
Thalamic infarcts Katayama fever Jacksonian Sz Klatzkin's Tumor PUD-like Halzoun Loeffler's Syndrome
Thalamic infarcts - Jap B Katayama fever, Jacksonian Sz - Schistosoma Klatzkin's Tumor - C sinensis PUD-like - Heterophyes, Metagonimus Halzoun - F hepatica Loeffler's Syndrome - Ascaris
Drugs for:
Tuberculoid Leprosy
Lepromatous Leprosy
Erythema nodosum Leprosum
Tuberculoid Leprosy
- Dapsone + Rifampicin
Lepromatous Leprosy
- Dapsone + Rifampicin + Clofazimine
*grows in foot pad of Armadillo
Erythema nodosum Leprosum
- Thalidomide
Gram positive funal-like
aerial hyphae
Nocardia asteroides
Mx: SMX-TMP (‘SNAP’)
*SMX Nocardia ; Actinomyces Pen
- CM: mycetoma & abscesses (lung & brain “orange colonies”
- Fite Faraco Stain
Fite faraco Stain Eaton medium Regan Lowe Agar MAnnitol Salt Agar BSK Medium Frei Test Cycloxidine Culture Circumoral Precipitin test Loeffler's medium Harada-Mori
Fite faraco Stain - Nocardia Eaton medium -Mycoplasma Regan Lowe Agar - Bordetella Mannitol Salt Agar - Staph BSK Medium - Borrelia burg Cycloxidine Culture - Chlamydia Frei test - Chlamydia (LGV) Circumoral Precipitin test - Schistosoma Loeffler's medium - C diphtheriae Harada-Mori - Strongyloides
Cold Agglutinin Syndrome
Mycoplasma pneumoniae
- cold agglutinins - against RBC
- cold temp: clots ; room temp: unclots
*toll like receptors 2 protein (P1 adhesin)
MC Infectious cause of SJS
Mycoplasma pneumoniae
Lacks Kreb’s cycle hence cannot be cultured in vitro
Treponema pallidum
Ixodes ticks Dermacentor Peduculus humanus Civet cat Horseshoe bat Culex mosquito Mansonia Blackfly Deer fly Mango fly
Ixodes ticks - Borrelia burgdorferi; Babessia Dermacentor - Franciscella; Erlichia Peduculus humanus - Borrelia recurrentis Civet cat - Corona (IH) Horseshoe bat - Corona (reservoir) Culex mosq - Jap B, Wuchureria Mansonia - Brugia Blackfly (female, Simulum) - Onchocerca Deer fly, Mango fly (Chrysops) - Loa
Reduviid bug (Triatoma) Tse tse fly (Glossina) Bivalve mollusks Sandfly (Phlebotomus) Oncolmelania hupensis quadrasi Antemelania asperata Sundathelphusa phil
Reduviid bug (Triatoma) - Tcruzi
Tse tse fly (Glossina) - T brucei
Bivalve mollusks - Dinoflagellates
Sandfly (Phlebotomus) - Leishmania
Oncolmelania hupensis quadrasi - Schistosoma (IH)
Antemelania asperata, Sundathelphusa phil - Paragonimus (IH)
Cutaneous Larva Migrans
Larvae Currens
Visceral Larva Migrans
Ocular larva Migrans
‘serpginous tracks’
CLM -Hookworms
Larvae Currens -Strongyloides
Visceral Larva Migrans, Ocular larva Migrans - Toxocara canis
Erythema chronicum migrans
Lyme Dsx
- Borrelia burgdorferi
2- AV block; Bell’s palsy
3- onion skin lesion; acrodermatitis chronica atrophicans
Owl's eyes Koplik's spot Nagayama spot Negri bodies Habestadter Prwazeki Flower-like nucleus Thread-like virus Threadworm
Owl's eyes - CMV (Herpes) Koplik's spot - Measles Nagayama spot - Roseola Negri bodies - Rhabdo Habestadter Prwazeki - Chlamydia trachomatis A-C Flower-like nucleus - HTLV (Retro) Thread-like virus - Ebola (Filo) Threadworm - Strongyloides (Nema)
Elementary body
Reticulate body
Chlamydia Elementary body - infectious - inactive - extracellular - enters body by endocytosis
Reticulate body
- active
- intracellular
Inclusions in Chlamydia trachomatis type A-C
Haberstadter Prowazek
Henderson Peterson bodies Warthin Finkeldy bodies Guanerdin bodies Ernst babes bodies Meyer's Kouvenaar's bodies
Henderson Peterson bodies - Molluscum (Pox)
Warthin Finkeldy bodies - Measles (Paramyxo)
Guanerdin bodies - Vario/Smallpox (Pox)
Ernst babes bodies - Corynebac
Meyer’s Kouvenaar’s bodies - Filariasis
p24 gp120 gp41 tat rev vif nef vpu
p24 (gag)
- nucleopcapsid
- group specific (SEROLOGIC MARKER)
gp120 (env)
- attachment
- V3 LOOP - most immugenoc region
- changes rapidly
gp41 (env)
- fusion
tat -activates transcription rev -transpot mRNA to cytoplasm vif -increases hypermutation nef -decreases CD4 & Class I MHC vpu -increases virion release
Maltese cross Honeycomb vesicles Barrel shaped proglotids Barrel shaped eggs Forked tail
Maltese cross - Babesia
Honeycomb vesicles - Echinococcus multilocularis
Barrel shaped proglotids - Dipylidium caninum
Barrel shapes eggs - Trichuris
Forked tail - Schistosoma
Anchovy-sauce aspirate Durck granulomas Ring- enhancing lesions Ring - shadow opacity Intracranial calcifications Mott cells Mariner's wheel Nocturnal periodicity Nocturnal wheezing
Anchovy-sauce aspirate - E. hystol
Durck granulomas - Malaria
Ring- enhancing lesions - T gondii (enceph)
Ring - shadow opacity CXR - Paragonimus
Intracranial calcifications - T gondii (congenital)
Mott cells - T brucei
Mariner’s wheel - Paracoccidioses
Nocturnal periodicity, Nocturnal wheezing - Filariasis
Calabar swelling - Loa Loa
Heterophile Monospot Test
(+) EBV
(-) CMV T.gondii
