Pharma

Question 0

Movement of drug molecules within biologic membranes

Answer 0

Permeation

Question 1

Water & Lipid solubility of Weak Acid & Base

Answer 1

WATER SOL

• weak acid: unprotonated
• weak base: protonated

LIPID SOL

• weak acid: protonated
• weak base: unprotonated

Question 2

Zero Order Elimination

50% every half life

Answer 2

'WHAT PET'
Warfarin
Heparin
Aspirin
Tolbutamide
Phenytoin
Ethanol
Theophylline

Question 3

Diminished response after drug administration

Drugs?

Answer 3

Tachyphylaxis

*'MED Love CNN HD'
Metoclopromide
Ephedrine
Dobutamine
LSD
Calcitonin
Nitroglycerine
Nicotine
Hydralazine
Desmopressin

Question 4

Amout / fraction of srug administered that reaches systemic circulation

Answer 4

Bioavailability

*determined by AREA UNDER THE CURVE

Question 5

Standard in vitro test for Mutagenicity

Answer 5

AMES Test

Question 6

Sjogren Syndrome?
Sicca Syndrome?

Drug?

Answer 6

Sjogren (triad)

• Sicca syndrome: xeroatomia & xerophthalmia
• RA

Mx: Pilocarpine (M3R activator)

Question 7

Ogilvie Syndrome

Drug mx?

Answer 7

Neostogmine
-AchE inhibitor

*Acute Colonic Pseudo Obstruction

Question 8

Indirect acting Cholinomimetic

(AchE inhibitor) used in Alzeimer’s

Answer 8

Rivastigmine

*SimDrx: Galantamine Donepezil Tacrine

Question 9

Anti-Muscatinic used in Parkinson’s

Answer 9

Benzteopine
(anti-M; restores NT balance in Basal Ganglia)

*SimDrx: Biperiden. Trihexyhenidyl

Question 10

Cholinergic Antag (Anti-M) used in Motion sickness

Answer 10

Scopolamine

blocks ALL M receptors; antag to Histamine & Serotonin

Question 11

Dose Dependent Actions of Dopamine

Answer 11

1-5mcg/kg/min : D1 vasodil splanchnic & renal vasculature
5-10mcg/kg/min : B inc renal BF, HR, cardiac contractility, CO
10-15mcg/kg/min: £ vasoconstriction, inc BP

Question 12

Mx of Rebound HPN secondary to Clonidine overdose

Answer 12

Phentolamine

Non selective £ Antag : £1>£2

Question 13

Drx used for Presurgical Pheochronocytoma

Answer 13

Phenoxybenzamine
(Non Selective £ Antag : £1>£2)

*covalent bond formation - long half life)

Question 14

Drug induced Lupus

Answer 14

'HIPP'
Hydralazine
INH
Procainamide
Penicillamine

Question 15

SE: Gingival Hyperplasia

Answer 15

Verapamil - non-dihydropyr CCB
Nifedipine - dihydropyr CCB
Cyclosporine - NSAID (-)IL
Phenytoin

Question 16

Mx of Class 1A Antiarrhythmia

Answer 16

Na-Lactate

*‘I Am the Queen who Proclaimed Diso Pyramid’
Class IA - Quinidine Procainamide Disopuramide

Question 17

PGF2£ analog used in Galucoma but may cause permanent eye color change

Answer 17

Latanoprost

*Carboprost - PGF2£ analog used as abortifacient & to ctrl post partum hemox

Question 18

Triad of Hemochromatosis

Answer 18

Cirrhosis
DM
Skin pigmentation

Question 19

Organophosphate toxicity

Answer 19

Atropine - anti-M
Pralidoxime - AchE regenerator

*admin within 4-6hrs

Question 20

Performance ehnhancing drug used by athletes

Answer 20

Epoetin £
-EPO R agonist

*SimDrxs: Methoxy polyethelene, DarbePOETIN £, Glycon-POETIN B

Question 21

Recombinant form of endogenous cytokine w/c activates IL-11 Rs

Answer 21

Oprelvekin
(Megakaryocyte GF)

*SimDrx: Thrombopoietin

Question 22

SAMSTER TRIAD

Answer 22

ASA Hypersensitivity
'ANA'
ASA sensitivity
Nasal polyps
Asthma

Question 23

Anti-Plt used during PCI to prevent restenosis

Answer 23

Abxicimab
(anti-gpIIb-IIIa binding to Fibrinogen)

*SimDrxs: Tirofiban Eptifibatide

Question 24

DOC for Pulmonary HPN

Answer 24

Epoprostenol | PGI2 analog

Question 25

Omalizumab Abciximab Infliximab Adalimumab

Answer 25

Omalizumab - anti-IgE in BA Abciximab, Cilostazol (Pletal) - Phosphodiesterase III inhib - antiplt Infliximab, Adalimumab, Etanercept - DMARD binds to TNF£ ^ ^ causes REACTIVATIONS of TB HepB, AutoAb formation, Lymphoma

Question 26

Corneal deposits

Answer 26

Amiodarone - cornea & skin - Class III with Class IA antiarrythmic effect Chloroquine - nightmares - Anti-Malaria; DMARD T Lympho response suppression

Question 27

Date-Rape drugs

Answer 27

Alcohol - MC Gamma Hydroxybutyrate Flunitrazepam -long acting Benzodiazepine * SimDrxs: Diazepam Flurazepam Quazepam CHLORazepate CHLORdiazepoxide (longest t1/2 36-200hrs) * short acting: MidaZOLAM TriaZOLAM Oxazepam * int acting: LoraZEPAM ClonaZEPAM Alprazolam

Question 28

For pxs with Sleep disorders

Answer 28

'Zzzz' Zolpidem Zaleplon Eszopiclone

Question 38

Trigeminal Neuralgia DOC

Answer 38

Carbamazepine | - TCA AntiSeizure

Question 39

Cytochrome P450 Inhibitors

Answer 39

``` 'SICKER V GAQ' Sulfonamides INH Cimetidine Ketoconazole Erythromycin Ritonavir Valproic Acid Grapefruit Juice Amiodarone Quinidine ```

Question 40

Cytochrome P450 Inducer

Answer 40

``` 'BERP C GSS' Barbiturates Ethanol Rifampicin Phenytoin Carbamazepine Griseofulvin Smoking St Worts ```

Question 41

Pseudomembranous colitis

Answer 41

'CAC' Clindamycin Ampicillin Cephalosporins (3rd gen)

Question 42

Post-Herpetic neuralgia | Allodynia

Answer 42

Gabapentin - GABA derivative anticonvulsant - inhib Ca channels; inc GABA release *SimDrx: Pregabalin

Question 43

AntiSeizure contraindicated in Schiz pxs due to Psychosis adverse effect

Answer 43

Leviteracetam - Piracetan anyiconvulsant - sel binds Synaptic Vesicle Protein SV2A - modifies glutamate & GABA release

Question 44

Anticonvulsant for Lennox Gastaut & West Syndrome

Answer 44

Topiramate - monosaccharide derivative - most number of MOA & toxicities (myopia galycoma urolithiasis memory impairment)

Question 45

Sz of diff types Psych & behavioral abn Dev delay

Answer 45

Lennox-Gastaut Syndrome

Question 46

Infantile Spasm Dev regress EEG: Hipp's Arrythmia -pathog

Answer 46

West Syndrome *Infantile spasm - Clonazepam

Question 47

Reversal agt for Rocuronium

Answer 47

Sugammadex

Question 48

Used for pxs with Strichnine posoning | For Lethal inj Euthanasia

Answer 48

Pancuronium - Non-dep skel muscle relaxant - competitive antag at SkM NICOTINIC Ach R - moderate block of CARDIAC MUSCARINIC Ach R