Microbio - virology Flashcards Preview

Step 1 > Microbio - virology > Flashcards

Flashcards in Microbio - virology Deck (22):
1

Three types of viral structure

naked with icosahedral capsid
enveloped with icosahedral capsid
enveloped with helical capsid

2

Live attenuated viral vaccines (not killed) - humoral and cell-mediated

smallpox, yellow fever, rota, VZV, polio (Sabin), MMR, nasal influenza

3

Killed viral vaccines (RIP Always) - humoral only

Rabies, Influenza (injection), Polio (salk), HAV SalK = Killed

4

Viral genome rules

DNA - ds except for Parvo (ss), linear except for polyoma, papilloma, hepadna (circular), replicate in the nucleus!

RNA - ss except for Reo (eg rota, ds), replicate in the cytoplasm (except flu and retrovirus)

5

DNA virus characteristics

Hep B, Herpes, Adeno, Pox, Parvo, HPV, JC/BK


double-stranded, linear

6

Acute hemorrhagic cystitis

Adenovirus - also febrile pharyngitis, pneumonia, conjunctivitis

7

JC virus, BK virus (give the virus family)

Polyoma virus

Junky Cerebrum, Bad Kidney

8

Picornavirus

PERCH on a "peak" (pic-o)

Polio, Echo, Rhino, Coxsackie, HAV

***RNA virus, codes for 1 large polypeptide that is cleaved into many smaller active viral proteins***

9

positive vs. negative sense RNA

positive sense = 5' --> 3', can be directly translated, is acts as viral mRNA

negative sense = 3' --> 5', complementary to viral mRNA, must carry RNA polymerase

10

negative-stranded viruses, which carry their own RNA-dependent RNA polymerase

Always Bring Polymerase Or Fail Replication

Paramyxo (RSV/parainfluenza/mumps/measles)
Orthomyxo (Influenza)
Filo (Ebola)
Rhabdo (rabies)

11

Rhinovirus

acid-labile - destroyed by stomach acid, no effect on GI tract

12

Rotavirus

villous destruction with apical atrophy, decreased Na absorption, loss of K

13

Influenza (orthomyxo)

hemagglutinin (promotes viral entry), neuraminidase (promotes progeny virion release)

risk of bacterial superinfection with Staph Aureus

14

genetic shift vs. drift

Sudden Shift is deadlier than graDual Drift

15

Paramyxo

PRM

- parainfluenza (croup), RSV, mumps/measles

- all have surface F protein (causes respiratory epithelial cells fuse)

16

Rhabdo

Rabies - Negri bodies in neurons (Purkinje/hippocampus), retrograde transport on axons after binding to Ach receptors

17

Hepatitis letters (A, B, C, D, E)

HAV: Asymptomatic, Acute, Alone
HBV: Blood, Birth, Baby-making (sex)
HCV: Chronic, Cirrhosis, Carcinoma, Carrier
HDV: Defective, Dependent
HEV: Enteric, Expectant, Epidemic

18

HBV serologies

6 phases
Active infection: HbSAg, HBeAg, IgM
Window: HBeAg, anti-HBe, IgM
Chronic (high infec.): HBsAg, HBeAg, IgG
Chronic (low infec): HBsAg, anti-HBe, IgG
Recovery: anti-HBs, anti-HBe, IgG
Immunized: anti-HBs, IgG

19

HIV facts to know

diploid genome - 2 molecules of RNA

Homozygous CCR5 mutation = immunity

Four stages of infection - Flu-like, Feeling fine, Falling count, Final crisis

20

HBeAg

indicates replication, infectivity

Immunized: no anti-HBe since there was never infection

21

HIV structural genes (3 total)

3 structural genes -

env (120 = attachment to CD4 T cells, 41 = fusion and entry)
gag (capsid protein)
pol (reverse transcriptase, aspartate protease

22

RNA viruses

NOT HAPPY: not Hep B, Herpes, Adeno, Pox, Parvo, HPV, JC/BK