Pharm autonomics, side effects, toxicities Flashcards Preview

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Flashcards in Pharm autonomics, side effects, toxicities Deck (90):
1

Bethanecol

Ach agonist (M3)

Urinary retention

2

Methacholine

Ach agonist (M3)

Asthma test

3

Pilocarpine

Ach agonist (M3)

Open-angle and closed-angle glaucoma

4

Donepezil/galantamine/rivastigmine

AchE inhibitor (indirect Ach agonist)

Alzheimer's

5

Edrophonium

AchE inhibitor (indirect Ach agonist)

MG diagnosis

6

Neostigmine

AchE inhibitor (indirect Ach agonist)

Post-op reversal of Ach blockade

No CNS penetration

7

Physostigmine

AchE inhibitor (indirect Ach agonist)

Atropine toxicity

8

Pyridostigmine

AchE inhibitor (indirect Ach agonist)

Myasthenia gravis

9

Atropine

Ach muscarinic antagonist (anticholinergic)

Eye mydriasis

10

Benztropine

Ach muscarinic antagonist (anticholinergic)

Parkinson's and dystonia

11

Glycopyrrolate

Ach muscarinic antagonist (anticholinergic)

Reduce secretions pre-op

12

Ipratropium/tiotroprium

Ach muscarinic antagonist (anticholinergic)

COPD/asthma (prevent bronchoconstriction)

13

Oxybutynin

Ach muscarinic antagonist (anticholinergic)

Overactive bladder, reduce bladder spasms

14

Scopolamine

Ach muscarinic antagonist (anticholinergic)

Motion sickness

15

Albuterol/salmeterol

Sympathomimetic
B2>B1

asthma

16

Dobutamine

Sympathomimetic
B1>B2

Heart failure (inotropic)

17

Dopamine

Sympathomimetic
D1,D2 > B > a

Unstable bradycardia

18

Epinephrine

Sympathomimetic
B > a

Anaphylaxis, asthma, open-angle glaucoma

19

Isoproterenol

Sympathomimetic
Beta! 1 and 2

Electrophysiologic eval of arrhythmias

20

Norepinephrine

Sympathomimetic
alpha1 > alpha2 > beta1

hypotension (decreased renal perfusion)

21

Phenylephrine

Sympathomimetic
alpha1 > alpha 2

Hypotension (vasoconstrictor), ocular procedures, rhinitis

22

Amphetamine

Indirect sympathetic agonist

narcolepsy, obesity, ADHD

23

Cocaine

Indirect sympathetic agonist

Vasoconstriction, local anesthesia

24

Ephedrine

Indirect sympathetic agonist

nasal decongestion, urinary incontinence

25

Clonidine

Sympatholytic (alpha 2 antagonist)

Hypertensive emergency, ADHD, Tourette

26

alpha-Methyldopa

Hypertension in pregnancy

27

Phenoxybenzamine

Non selective Alpha blocker

Pheochromacytoma

28

Phentolamine

Non selective Alpha blocker

MAO-i pts who ate tyramine (old foods)

29

Prazosin/tamsulosin

Selective alpha-1 blocker

Urinary sx of BPH, PTSD, hypertension

30

Mirtazepine

Selective alpha-2 blocker

Depression

31

Acetaminophen toxicity treatment

NAC (replenishes glutathione)

32

AChE inhibitors, organophosphates toxicity treatment

Atropine

33

Amphetamines toxicity treatment

Ammonia chloride (to acidify urine)

34

Anti-cholinergics (atropine) toxicity treatment

Physostigmine and control hyperthermia

35

Benzodiazepines toxicity treatment

Flumanezil

36

B-blockers toxicity treatment

Glucagon

37

Carbon monoxide toxicity treatment

100% O2

38

Copper, arsenic, gold toxicity treatment

Penicillinamine

39

Cyanide toxicity treatment

Nitrite + thiosulfate

40

Digoxin toxicity treatment

Anti-digoxin Fab fragments

41

Heparin toxicity treatment

Protamine sulfate

42

Iron toxicity treatment

Deferoxamine

43

Lead toxicity treatment

EDTA, dimercaprol

44

Mercury toxicity treatment

Dimercprol

45

Methemoglobin toxicity treatment

Methylene blue

46

Opioids toxicity treatment

Naloxone, naltrexone

47

Salicylates toxicity treatment

NaHCO3 (alkaline urine), dialysis

48

TCAs toxicity treatment

NaHCO3 (plasma alkaline)

49

tPA, streptokinase, urokinase toxicity treatment

Aminocaproic acid

50

Warfarin toxicity treatment

FFP, Vit. K

51

Coronary vasospasm

Cocaine, sumatriptan, ergot alkaloids

52

Dilated cardiomyopathy

Anthracyclines (doxorubicin chemotherapy)

53

Torsades de Pointes

Quinidine/sotalol (Class 1a,3), macrolides, antipsychotics

54

Hot flashes

Tamoxifen, clomiphene

55

Hyperglycemia

Tacrolimus, protease inhibs, niacin, HCTZ, corticosteroids

56

Hypothyroidism

Lithium, amiodarone, sulfonamides

57

Acute cholestatic hepatitis, jaundice

Erythromycin

58

Diarrhea

Metformin, Erythromycin, Colchicine, Orlistat, Acarbose

Might Excite Colon On Accident

59

Hepatic necrosis

Halothane, death cap mushrooms, Valproic acid, Acetaminophen

60

Hepatitis

Rifampin, isoniazid, pyrazinamide, statins, fibrate

61

Pancreatitis

Didanosine, corticosteroids, alcohol, valproic acid, azathioprine, diuretics

62

Agranulocytosis

Ganciclovir, clozapine, carbamazepine, colchicine, methimazole, propylthiouracil (PTU)

63

Aplastic anemia

Carbamazepine, methimazole, NSAIDs, benzene, chloramphenicol, PTU

64

Gray baby syndrome

Chloramphenicol

65

G6PD deficiency hemolysis

isoniazid, sulfonamides, dapsone, primaquine, aspirin, ibuprofen, nitrofurantoin

66

Megaloblastic anemia

Phenytoin, methotrexate, sulfa drugs

67

Thrombocytopenia

Heparin

68

Thrombotic complications

OCPs, hormone replacement therapy

69

Fat redistribution

protease inhibitors, glucocorticoids

70

Gingival hyperplasia

Phenytoin, Ca channel blockers, cyclosporine

71

Hyperuricemia

Pyrazinamide, thiazides, furosemide, niacin, cyclosporine

72

Myopathy

Fibrates, niacin, colchicine, hydroxychloroquine, interferon-a, penicillinamine, statins, glucocorticoids

73

Osteoporosis

Corticosteroids, heparin

74

Photosensitivity

Sulfonamides, amiodarine, tetracyclines, 5-FU

75

Rash/SJS

anti-epileptic drugs (ie lamotrigine), allopurinol, sulfa drugs, penicillin

76

SLE-like syndrome

Sulfa drugs, hydralazine, isoniazid, procainamide, phenytoin, etanercept

77

Teet discoloration

Tetracyclines

78

Tendonitis/tendon rupture/cartilage damage

Fluoroquinolones

79

Parkinson-like syndrome

Antipsychotics, reserpine, metoclopramide

80

Seizures

Isoniazid, bupropion, imipenem, enflurane

81

Diabetes insipidus

lithium

82

Fanconi syndrome

Tetracycline

83

Hemorrhagic cystitis

Cyclophosphamide, ifosfamide

84

Interstitial nephritis

Methicillin, NSAIDs, furosemide

85

SIADH

Carbamazepine, cyclophosphamide, SSRIs

86

Pulmonary fibrosis

Bleomycin, amiodarone, busulfan, methotrexate

87

Cytochrome p450 inducers

Chronic alcohol
St. John's wort
anti-epileptics (Phenytoin, Phenobarbital, Carbamazepine)
Rifampin
Griseofulvin (antifungal)

88

Cytochrome p450 inhibitors

Acute alcohol
Amiodarone
Cimetidine
Ketoconazole
Sulfonamides
Isoniazid
Grapefruit juice
Quinidine
Macrolides

89

Cytochrome p450 substrates

Anti-epileptics
Theophylline
Warfarin
OCPs

90

Sulfa drugs

Probenecid, furosemide, acetazolomide, celecoxib, thiazides, sulfanomides, sulfasalazine, sulfonylureas