Pathology - derm Flashcards Preview

Step 1 > Pathology - derm > Flashcards

Flashcards in Pathology - derm Deck (27):
1

Layers of the epidermis

Corneum
Lucidum
Granulosum
Spinosum
Basale

2

Claudins and occludins

Tight junctions

3

Cadherins and action cytoskeleton

Adherens junction

4

Keratin and desmoplakin

Desmosome

5

Connexons

Gap junction

6

Keratin and basement membrane

Hemidesmosome

7

Integrins

Membrane proteins that attach to basement membrane

8

Hyperkeratosis

incr. thickness of stratum corneum

9

Acanthosis

Epidermal hyperplasia (incr. spinosum)

10

Normal melanocyte number with decr. melanin production

Albinism

Decreased tyrosinase activity, or defective tyrosine transport

Also caused by failure of neural crest migration during development

11

Autoimmune destruction of melanocytes

Vitiligo

Irregular areas of complete depigmentation

12

Inflammation of pilsebaceous unit

Acne

13

Pruritic eruption on flexor areas

Atopic dermatitis (eczema)

Face in infancy, then elbow fossa

14

Acanthosis with hyperkeratosis

Psoriasis

incr. spinosum, decr. granulosum (SSSS: soriasis, spinosum)

Pinpoint bleeding when scales are scraped off - Auspitz sign

15

Squamous epithelial proliferation with keratin-filled cysts

Seborrheic keratosis

If sudden appearance of multiple, then indication of underlying GI/lymphoid cancer

16

Location of edema in urticaria

Dermis

look for lymphatic dilation as well. Mediated by mast cell degranulation

17

Staph scalded skin syndrome

Exotoxin destroys keratinocyte attachments in granulosum only

heals completely

18

Toxis epidermal necrolysis

Destruction of epidermal-dermal junction

19

IgG antibody against desmoglein (desmosome component)

Pemphigus vulgaris

Acantholysis, flaccid intraepidermal bullae

20

IgG antibody against hemidesmosome

Bullous pemphigoid

linear immunofluorescence at epidermal-dermal junction (Abs are "bullow" the epidermis)

21

IgA at tips of dermal papillae

Dermatitis herpetiformis

Assoc. with celiac disease

22

Associations with acanthosis nigricans

hyperinsulinism

gastric adenocarcinoma

23

Sawtooth infiltrate of lymphocytes at dermal-epidermal junction

Lichen planus

assoc. with hep C

pruritic, purple, polygonal planar papules and plaques

24

UVA vs. UVB rays

UVA - tanning, photoaging
UVB - sunburn

25

Pink pearly nodules with telangiectasias, rolled borders, central crusting

Basal cell carcinoma

Palisading nuclei

26

Ulcerative red lesions with frequent scale, may spread to lymph nodes

Squamous cell carcinoma

Keratin pearls

27

Activating mutation in BRAF kinase, V600E

Melanoma

Tx: vemurafenib