Microbiology In Upper GI Tract (Quiz) Flashcards

(47 cards)

1
Q

is Bacteroides anaerobic or aerobic

A
  • anaerobic
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2
Q

is Acitnomyces anaerobic or aerobic

A
  • anaerobic
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3
Q

is Clostridium anaerobic or aerobic

A
  • anaerobic
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4
Q

what is the most common cause of infectious esophagitis

often associated with

what is its aerobic status

A
  • Candida albicans
  • uncontrolled HIV or immunocompromisation
  • facultative anaerobe
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5
Q

which are greater in number, aerobes or anerobes

A
  • anaerobes

- >1000:1

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6
Q

which are the prominent phyla of anaerobes in the GI Tract

A
  • bacteroidetes

- firmicutes

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7
Q

most anaerobic infections are

A
  • mixed infections containing both anaerobic and aerobic bacteria
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8
Q

plaque is composed of

what do they secrete

A
  • bacterial biofilms

- exopolysaccharides

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9
Q

which bacteria causes SUPRAgingival plaque associated biofilm

A
  • actinomyces

A IN SUPRA STARTS THE A HERE

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10
Q

which bacteria causes SUBgingival plaque associated biofilm

A
  • Bacteroides

B IN SUB STARTS THE B HERE

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11
Q

classification of bacteroides

A
  • gram negative
  • non-spore forming
  • anaerobic
  • bacilli
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12
Q

Bacteroides found where

A
  • oropharynx
  • intestinal tract
  • female genital tract
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13
Q

what is the most predominant bacteria found in the GI tract

esp

A
  • Bacteroides

- B. fragilis

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14
Q

what is the most common genus isolated from anaerobic infections

what specific bug

A
  • Bacteroides

- B. fragilis

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15
Q

for bacteroides to cause disease, what is required

A
  • breach of epithelial cell barrier allowing access to deeper tissues.
  • unable to invade cells or tissues itself
  • requires synergy with other bacteria
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16
Q

classification of Actinomyces species

A
  • gram positive
  • non-spore forming
  • anaerobic
  • bacilli
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17
Q

Actinomyces is usually associated with

why

are adults or children more affected

A
  • following dental procedures (odontogenous)
  • part of normal oral flora
  • adults more than children
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18
Q

Actionmyces Israelii causes

characteristics of infection

treatment

A
  • lumpy jaw
  • abscesses, mass lesion, or swelling of soft tissues
  • sulfur granules drained from them
  • long term antibiotic therapy
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19
Q

clostridium is part of what phylum

full classification of clostridium

A
  • Firmicutes
  • gram positive
  • spore forming
20
Q

products of clostridium fermentation have what characteristic

21
Q

which clostridia are associated with gas gangrene

how can they spread

A
  • perfringens

- septicum - spread via bloodstream

22
Q

which clostridia are associated with food poisoning and wound infection

23
Q

which clostridia are associated with antibiotic- associated diarrhea and colitis

24
Q

endotoxins are part of what type of bacteria

how so

A
  • gram negative

- part of LPS (lipid A + polysaccharide)

25
what is an exotoxin
- any secreted toxin
26
what is an enterotoxin
- a secreted toxin that targets enteric cells
27
what kind of toxins do C. tetani and C. bolulinum have
- A - active | - B - binding
28
tetanus toxin causes what
- prevents release of inhibitory neurotransmitter | - causes spasticity (tetanus spasm)
29
botulinum toxin causes what
- prevents release of stimulatory neurotransmitter | - causes paralysis
30
toxin of C perfringens what does it do
- alpha toxin | - lecithinase degrades tissue and cell membrane
31
toxins of C. difficile what do they do
- A and B toxins - glucosylate Rho GTPase - cytotoxic and inflammatory
32
traumatic gas gangrene is caused by what allows the bug to metabolize and contaminate the wound
- clostridium perfringens | - tissue damage
33
spontaneous gas gangrene caused by what allows the gut to enter the bloodstream
- clostridium septicum | - breaks in GI mucosa
34
between traumatic gas gangrene and spontaneous gas gangrene, which is the most deadly
- clostridial myonecrosis spontaneous gas gangrene | - mortality up to 100%
35
what results from compromised intestinal barrier function
- peritonitis
36
organisms responsible for intra-abdominal infections role of capsular polysaccharide fragment
- Enterobacteriaceae | - B. fragilis - PMN recruitment
37
why do we use a woundvac in treatment of anaerobic infections
- allows antibiotics to penetrate better
38
what antibiotics are always active against anaerobes
- metronidazole - carbapenems - beta-lactams Make Bacteria Cry
39
what antibiotics are never active against anaerobes
- aminoglycosides (-mycin) - Tmp/Smx - Aztreonom Always Too Awkward so they won't do it
40
how to treat candidiasis
- fluconazole
41
what does H. pylori use to colonize
- flagellar motility
42
H. pylori replicates at pH as high as
- 7.6
43
how H. pylori causes damage
- mucinases and injected effectors damage epithelial cells and induce inflammation
44
diversity of H. pylori virulence factors
- cytotoxin associated genes and type 4 secretion system genes on mobile Cag pathogenicity islands
45
treatment of H. pylori
- combination of antibiotics - proton pump inhibitors - bismuth subsalicylate
46
low solubility of O2 and poor diffusibility means what about anaerobes
- they can be really close to the surface
47
appropriate specimens for collection
- aspirates of abscesses, tissue, blood