MIDTERMS EVALS 2 (2023) Topic/s: Glycoproteins, Hormone Action, Membrane Structure, Muscle and Cytoskeleton Flashcards
(54 cards)
1
Q
First intracellular signal discovered in
mammalian cells
A
cAMP
2
Q
Glucocorticoid directly binds to p65 subunit
of NF-kb and inhibits its activation
TRUE OR FALLS
A
TRUE
3
Q
High energy conformation
A
Myosin-ADP-Pi complex
4
Q
Inhibits F-actin-myosin interaction
A
Troponin I
5
Q
Uses JAK/STAT pathway
A
Growth hormone
6
Q
Pingpong mechanism is reversible
TRUE OR FALLS
A
TRUE
7
Q
Not true about Smooth muscle
A
Sarcomere is aligned
8
Q
Absence of dynein will result in the following except: A. Situs inversus totalis B. Male sterility C. Muscle dystrophy D. Immobile cilia and flagella
A
C. Muscle dystrophy
9
Q
Stimulate Adenylyl Cyclase
A
ADH
10
Q
Compound that terminates the activity
of cAMP
A
Phosphodiesterase
11
Q
Effect of Phosphodiesterase
A
Decreases cAMP levels
12
Q
Calmodulin
A
Binds 4 Ca
13
Q
Attachment of P. falciparum is mediated by what glycoprotein? A. O-linked B. N-linked C. GPI-linked
A
C. GPI-linked
14
Q
DNA transfection
A. Endocytosis
B. Exocytosis
A
A. Endocytosis
15
Q
The relax phase of muscle contraction A. Actin head become accessible B. S-1 head of myosin hydrolyze ATP C. Inorganic phosphate is released D. Intercellular levels of ATP drops
A
B. S-1 head of myosin hydrolyze ATP
16
Q
Effect of nitroglycerin
A
Smooth muscle relaxation and vasodilation
17
Q
Na+K+ pump, 3 Na pumped outside
plasma membrane through?
A. Phosphorylation
B. Dephosphorylation
A
A. Phosphorylation
18
Q
True regarding group I hormones
A
Longer duration of action
19
Q
Group II hormone is characterized by
A
Rapid response
20
Q
Reuptake of macromolecules where there is a finite number of receptors in the plasma membrane. A. IPhagocytosis B. Absorptive pinocytosis C fluid phase pinocytosis D exocytosis
A
B. Absorptive pinocytosis
21
Q
True about glucocorticoids A. Receptor is found at the nucleus B. Assoc of hormone causes attachment of corepressor = activation C. Receptor is bound by HSP90 D. NOTA
A
C. Receptor is bound by HSP90
22
Q
This is responsible for the negative charge of mucins A. Presence of intermolecular noncovalent bonds B. Presence of proteases C. Presence of NeuAc and Sulphate
A
C. Presence of NeuAc and Sulphate
23
Q
Multinucleated cell responsible for bone
resorption?
A
Osteoclast
24
Q
Has a glycerol backbone
A
Phosphoglyceride
25
```
Which of the statements regarding peripheral
membrane protein is true?
A. Reacts extensively with hydrophobic
core
B. Released from the hydrophilic region
through salt solutions with high ionic
content
C. Requires use of detergent
D. Usually globular
```
B. Released from the hydrophilic region
through salt solutions with high ionic
content
26
```
Filaments found in eukaryotic cells except
A. Microfilaments
B. Microtubules
C. Intermediate Filaments
D. Macrofilament
```
D. Macrofilament
27
Common pentasaccharide of N-linked
| glycoproteins
Man3GlcNAc2
28
```
Promotes release of calcium from intracellular
stores in ER
A. IP3
B. DAG
C. Both
D. None
```
A. IP3
29
Not O-linked
Asn-GlcNAc
30
Cholera toxin
Modifies a-subunit
31
```
Major intracellular ions except:
A. K+
B. Mg+
C. HCO3-
D. PO4
```
C. HCO3-
32
Enzymatic marker for endoplasmic reticulum
Glucose-6-phosphatase
33
Specialized exoplasmic area rich in
| sphingolipids, cholesterol and protein
Lipid raft
34
Area in epithelial cell just below the apical
region which protects from diffusion of
macromolecules
Tight junction
35
Structure that permits direct transfer of
| molecules from one cell to another
Gap junctions
36
Ion channel opens via binding of molecule
| to a receptor
Ligand gated
37
Movement of glucose in the apical surface
Symport
38
Allows glucose that accumulates in the
cell to move across the basolateral membrane
into the ECF
Uniport
39
Strong preference for Dol-P-P Glc-
| NAc2Man9Glc3 and is also innibited by tunicamycin
Oligosaccharide:protein transferase
40
All of the following are true, except:
A. The sarcomere is the region between two
Z lines
B.??
C. Glycogen, ATP, Phosphocreatine are
stored in the sarcolemma
D. ..bisected by the dense and narrow Z line
C. Glycogen, ATP, Phosphocreatine are
| stored in the sarcolemma
41
Effect of atriopeptins
A. Increase cGMP
B. Inhibit guanylyl cyclase
C. Diuretic
A. Increase cGMP
42
Unsaturated FA tail bind to which carbon
| atom
Carbon 2
43
A disease in a-dystroglycan which protrudes
| in the membrane
Congenital muscular dystrophy
44
Influenza virus
NeuAc
45
True statement regarding thyroid hormone
Association of hormone to receptor results
| in the dissociation of the co-repressor
46
```
Minimizes the hydrophilic characteristic
of the peptide bond?
A. Alpha helical structure
B. Beta helical structure
C.(micro sign) helical structure
D. € helical structur
```
A. Alpha helical structure
47
```
Movement of water through water
channels
A. Abc transporter
B. Aquaporins
C. P transporter
D. Water transporter
```
B. Aquaporins
48
Decreased pH during sleep and RBC
| lysis
Paroxysmal Nocturnal Hemaglobinuria
49
Dolichol PP deficiency
Congenital disorder of glycosylation type
| 1
50
```
Unique to striated muscles except
A. Troponin
B. Tropomyosin
C. ATP
D. Calsequestrin
```
A. Troponin
51
```
Chondrodysplacia gene mutation
A. Type 1 collagen
B. Type 2 collagen
C. Fibroblast growth factor receptor
D. Both type 2 and fibroblast growth factor
receptor
```
D. Both type 2 and fibroblast growth factor
| receptor
52
Mutation of UDP-Fucose transporter
Leukocyte Adhesion Defect
53
Relaxation phase
Hydrolysis of ATP
54
Primary sugar found both in O-linked
| and N-linked glycoproteins?
N-Acetylneuramic acid
